The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Reduced d-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients
Abstract
Several lines of evidence suggest that D-serine, an endogenous agonist of the glycine site on the NMDA receptors, might play a role in the pathophysiology of schizophrenia. The purpose of this study was to determine whether levels of D- and L-serine or D-serine ratio (D-serine/total serine) in cerebrospinal fluid (CSF) were altered in first episode and drug-naive schizophrenic patients. The CSF levels of D- and L-serine in 25 male first episode and drug-naive schizophrenic patients and 17 age-matched male healthy subjects were measured using a column-switching high performance liquid chromatography system. The percentage of D-serine in the total serine of patients was significantly (z = -2.01, p = 0.044) lower than that of controls. This study suggests that synthetic or metabolic pathways of D-serine may be abnormal in the brain of drug-naive schizophrenic patients, supporting the NMDA receptor dysfunction hypothesis of schizophrenia.
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“Post-mortem studies of the brain of patients with schizophrenia have revealed lower levels of expression of the obligate NMDAR subunit GRIN1 (glutamate receptor ionotropic, NMDA 1), increases in the expression of the endogenous NMDAR antagonist kynurenate, and a reduction in levels of the NMDAR co-agonist D-serine and the enzyme that catalyses its production, D-serine racemase 10,[16][17][18] .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [17]
Citations
Cites
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Diagnostic and Statistical Manual of Mental Disorders
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Recent advances in the phencyclidine model of schizophrenia
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Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685
The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia
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Decreased Serum Levels of D-Serine in Patients With Schizophrenia
Hashimoto, K., Fukushima, T., Shimizu, E., Komatsu, N., Watanabe, H., 篠田, 直., Nakazato, M., Kumakiri, C., Okada, S.-I., Hasegawa, H., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.572 · Cited by 489
Self-citationSchizophrenia and Glutamatergic Transmission
Tamminga, C. A. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i1-2.20 · Cited by 382
Free d-aspartate and d-serine in the mammalian brain and periphery
Hashimoto, A., & Oka, T. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00019-1 · Cited by 332
Novel Neurotransmitters and Their Neuropsychiatric Relevance
Snyder, S. H., & Ferris, C. D. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1738 · Cited by 263
Dysfunction of Glia-Neuron Communication in Pathophysiology of Schizophrenia
Hashimoto, K., Shimizu, E., & Iyo, M. (2005) · Current Psychiatry Reviews · doi:10.2174/1573400054065569 · Cited by 75
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Astrocyte Control of Synaptic Transmission and Neurovascular Coupling
Haydon, P. G., & Carmignoto, G. (2006) · Physiological Reviews · doi:10.1152/physrev.00049.2005 · Cited by 1,371
Lisman, J. E., Coyle, J. T., Green, R. W., Javitt, D. C., Benes, F. M., Heckers, S., & Grace, A. A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.005 · Cited by 1,010
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
Coyle, J. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9062-8 · Cited by 917
Increased Levels of Glutamate in Brains from Patients with Mood Disorders
Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 631
Self-citationJavitt, D. C. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)78003-5 · Cited by 568
Metadata
- Authors
- Hashimoto, K., Engberg, G., Shimizu, E., Nordin, C., Lindström, L. H., & Iyo, M.
- Affiliations
- Chiba University (JP)
- Karolinska Institutet (SE)
- Linköping University Hospital (SE)
- Uppsala University (SE)
- Corresponding author
- Hashimoto, Kenji
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 29
- Issue
- 5
- Pages
- 767-769
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2078450450
- Cited by
- 267
- References
- 13
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 11 · 2023: 10 · 2022: 6 · 2021: 7 · 2020: 12 · 2019: 18 · 2018: 15 · 2017: 12 · 2016: 16 · 2015: 13 · 2014: 12 · 2013: 14 · 2012: 14
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- D-serine, L-serine, cerebrospinal fluid, schizophrenia, first-episode schizophrenia, drug-naive patients, NMDA receptor, serine metabolism
- MeSH terms
- Adolescent, Adult, Chromatography, High Pressure Liquid, Humans, Male, Schizophrenia, Serine, Stereoisomerism, Receptors, N-Methyl-D-Aspartate
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