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Cited by 17Stress Responses and CortisolAdrenal Hormones and DisordersSubstance Abuse Treatment and Outcomes

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Hypothalamic–pituitary–adrenal axis activity, dehydroepiandrosterone sulphate and their relationships with aggression in early and late alcohol withdrawal

Ozsoy, Saliha, Esel, Ertugrul·2008·Progress in Neuro-Psychopharmacology and Biological Psychiatry
DOI 10.1016/j.pnpbp.2007.08.034
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Abstract

The study aims at investigating the relationship between hypothalamic-pituitary-adrenal (HPA) axis alterations and aggression level in alcoholic patients during early and late alcohol withdrawal. Serum levels of basal cortisol and dehydroepiandrosterone sulphate (DHEAS) were measured three times, and cortisol and DHEAS response to dexamethasone twice during the early and late withdrawal periods in alcohol dependent males (n=30) and once in healthy control males (n=20). Abnormal cortisol non-suppression response to dexamethasone in dexamethasone suppression test (DST) was observed in some proportion of the patients in early withdrawal, which normalized in late withdrawal. The study revealed reduced basal DHEAS levels and reduced DHEAS response to dexamethasone in late withdrawal. When the patients were assessed in two separate groups as high- and low-aggressives, in the high-aggression group abnormality in DST was observed during both early and late withdrawal periods, in the low-aggression group it was observed only in early withdrawal. While basal DHEAS levels were low in the high-aggression group only in early withdrawal, it was reduced in the low-aggression group during late withdrawal period. Some alterations of the HPA axis during alcohol withdrawal might be associated not only with alcohol use per se but also with aggressivity tendency of alcoholic patients.

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Metadata

Authors
Ozsoy, S., & Esel, E.
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2008-02
Volume
32
Issue
2
Pages
340-347
ISSN
0278-5846 (ISSN-L)
DOI
10.1016/j.pnpbp.2007.08.034
OpenAlex
W2088955828
Cited by
17
References
2
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2012: 2
FWCI
0.13
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Erciyes Üniversitesi
  • Universidade do Porto
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
hypothalamic-pituitary-adrenal axis, alcohol withdrawal, aggression, dehydroepiandrosterone sulfate, cortisol, dexamethasone suppression test, alcoholism, HPA axis dysregulation, glucocorticoid response
MeSH terms
Adult, Aggression, Ethanol, Alcoholism, Dexamethasone, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Substance Withdrawal Syndrome, Dehydroepiandrosterone Sulfate, Alcohol-Induced Disorders, Control Groups

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