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Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: A meta-analysis
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“SJW modulates serotonin levels and reduces psychological stress, which explains its widespread use as an herbal treatment for depression [79].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [79]
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Research works printed but not linked: 24
- Behnke, 2002, Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression, Adv Ther, 19, 43, 10.1007/BF02850017 · DOI
- Bjerkenstedt, 2005, Hypericum extract LI 160 and fluoxetine in mild to moderate depression: a randomized, placebo-controlled multi-center study in outpatients, Eur Arch Psychiatry Clin Neurosci, 255, 40, 10.1007/s00406-004-0532-z · DOI
- Brenner, 2000, Comparison of an extract of Hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study, Clin Ther, 22, 411, 10.1016/S0149-2918(00)89010-4 · DOI
- Butterweck, 2007, St. John's wort: role of active compounds for its mechanism of action and efficacy, Wien Med Wochenschr, 157, 356, 10.1007/s10354-007-0440-8 · DOI
- E/S/C/O/P Monographs, 2nd ed. the European Scientific Cooperative on Phytotherapy in collaboration with Thieme: 2003.
- Di, 2008, Clinical drugs that interact with St. John's wort and implication in drug development, Curr Pharm Des, 14, 1723, 10.2174/138161208784746798 · DOI
- Fava, 2005, A double-blind, randomized trial of St. John's wort, fluoxetine, and placebo in major depressive disorder, J Clin Psychopharmacol, 25, 441, 10.1097/01.jcp.0000178416.60426.29 · DOI
- Gastpar, 2005, Efficacy and tolerability of Hypericum extract STW3 in long-term treatment with a once-daily dosage in comparison with sertraline, Pharmacopsychiatry, 38, 78, 10.1055/s-2005-837807 · DOI
- Gastpar, 2006, Comparative efficacy and safety of a once-daily dosage of Hypericum extract STW3-VI and citalopram in patients with moderate depression: a double-blind, randomised, multicentre, placebo-controlled study, Pharmacopsychiatry, 39, 66, 10.1055/s-2006-931544 · DOI
- Harrer, 1999, Comparison of equivalence between the St. John's wort extract LoHyp-57 and fluoxetine, Arzneimittelforschung, 49, 289
- Hypericum Depression Trial Study Group, 2002, Effect of Hypericum perforatum (St. John's wort) in major depressive disorder: a randomized controlled trial, JAMA, 287, 1807, 10.1001/jama.287.14.1807 · DOI · Paper page
- Kalb, 2001, Efficacy and tolerability of Hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial, Pharmacopsychiatry, 34, 96, 10.1055/s-2001-14280 · DOI
- Kasper, 2006, Superior efficacy of St. John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298], BMC Med, 4, 14, 10.1186/1741-7015-4-14 · DOI
- Lecrubier, 2002, Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial, Am J Psychiatry, 159, 1361, 10.1176/appi.ajp.159.8.1361 · DOI
- Linde, 2005, St. John's wort for depression: meta-analysis of randomised controlled trials, Br J Psychiatry, 186, 99, 10.1192/bjp.186.2.99 · DOI
- Linde, 2005, St. John's wort for depression, Cochrane Database Syst Rev, 2, CD000448
- Moreno, 2006, Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample, Rev Bras Psiquiatr, 28, 29, 10.1590/S1516-44462006000100007 · DOI
- Papakostas, 2007, Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder. A replication of findings with the use of a double-blind, placebo-controlled trial of Hypericum perforatum versus fluoxetine, Neuropsychobiology, 56, 132, 10.1159/000115779 · DOI
- Rahimi, 2006, Pregnancy outcomes following exposure to serotonin reuptake inhibitors: a meta-analysis of clinical trials, Reprod Toxicol, 22, 571, 10.1016/j.reprotox.2006.03.019 · DOI
- Rahimi, 2008, Selective serotonin reuptake inhibitors for the management of irritable bowel syndrome: a meta-analysis of randomized controlled trials, Arch Med Sci, 4, 71
- Rahimi, 2008, Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials, Clin Ther, 30, 884, 10.1016/j.clinthera.2008.05.002 · DOI
- Schrader, 2000, Equivalence of St. John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression, Int Clin Psychopharmacol, 15, 61, 10.1097/00004850-200015020-00001 · DOI
- Szegedi, 2005, Acute treatment of moderate to severe depression with Hypericum extract WS 5570 (St. John's wort): randomised controlled double blind non-inferiority trial versus paroxetine, BMJ, 330, 503, 10.1136/bmj.38356.655266.82 · DOI
- van Gurp, 2002, St. John's wort or sertraline? Randomized controlled trial in primary care, Can Fam Physician, 48, 905
Cited by
Interactions Between Herbal Medicines and Prescribed Drugs: An Updated Systematic Review
Izzo, A. A., & Ernst, E. (2009) · Drugs · doi:10.2165/11317010-000000000-00000 · Cited by 801
Ravindran, A. V., Balneaves, L. G., Faulkner, G., Ortiz, A., McIntosh, D., Morehouse, R. L., Ravindran, L., Yatham, L. N., Kennedy, S. H., Lam, R. W., et al. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716660290 · Cited by 337
Sarris, J., Camfield, D., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.051 · Cited by 59
“SJW has been studied extensively fordepression (Sarris andKavanagh, 2009), and has revealed equivalent efficacy to conventional antidepressants (Rahimi et al., 2009).”
BackgroundUnified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy
Nehls, M. (2016) · Journal of Molecular Psychiatry · doi:10.1186/s40303-016-0018-8 · Cited by 41
Pastras, P., Aggeletopoulou, I., Bali, M., & Triantos, C. (2026) · Nutrients · doi:10.3390/nu18020183 · Cited by 1
Metadata
- Authors
- Rahimi, R., Nikfar, S., & Abdollahi, M.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 33
- Issue
- 1
- Pages
- 118-127
- ISSN
- 0278-5846
- Cited by
- 101
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.