Antioxidants as potential therapeutics for neuropsychiatric disorders
Open accessAbstract
Oxidative stress has been implicated in the pathophysiology of many neuropsychiatric disorders such as schizophrenia, bipolar disorder, major depression etc. Both genetic and non-genetic factors have been found to cause increased cellular levels of reactive oxygen species beyond the capacity of antioxidant defense mechanism in patients of psychiatric disorders. These factors trigger oxidative cellular damage to lipids, proteins and DNA, leading to abnormal neural growth and differentiation. Therefore, novel therapeutic strategies such as supplementation with antioxidants can be effective for long-term treatment management of neuropsychiatric disorders. The use of antioxidants and PUFAs as supplements in the treatment of neuropsychiatric disorders has provided some promising results. At the same time, one should be cautious with the use of antioxidants since excessive antioxidants could dangerously interfere with some of the protective functions of reactive oxygen species. The present article will give an overview of the potential strategies and outcomes of using antioxidants as therapeutics in psychiatric disorders.
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Antioxidants have shown promising therapeutic benefits in the treatment of psychiatric disorders.
“Importantly, antioxidants have shown promising therapeutic benefits in the treatment of psychiatric disorders and are subject to further investigation [126,127,140].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [140]
Supplementation with high doses of vitamins C and E and fish oil improves clinical symptoms of patients with schizophrenia and partially restored levels of antioxidants.
“Supplementation with high doses of vitamins C and E and fish oil has been found to improve clinical symptoms of patients with schizophrenia and partially restored levels of antioxidants (Pandya et al. 2013).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Pandya et al. 2013
Telomere shortening may be related to specific biological processes or endophenotypes more than to specific diagnostic categories, although this remains to be adequately tested.
“Since such biochemical abnormalities cut across traditional psychiatric diagnoses (Pandya et al., 2013; Rosenblat et al., 2014; Smyth and Lawrie, 2013), telomere shortening may be related to specific biological processes or endophenotypes more than to specific diagnostic categories, although this remains to be adequately tested.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Pandya et al., 2013
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References 161 · Cited by 222
- Authors
- Pandya, C. D., Howell, K. R., & Pillai, A.
- Affiliations
- Augusta University (US)
- Corresponding author
- Pillai, Anilkumar
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 46
- Pages
- 214-223
- ISSN
- 0278-5846 (ISSN-L)
- PMC
- PMC3615047
- OpenAlex
- W2013122369
- Cited by
- 222
- References
- 161
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 14 · 2023: 16 · 2022: 17 · 2021: 20 · 2020: 27 · 2019: 22 · 2018: 13 · 2017: 19 · 2016: 20 · 2015: 24 · 2014: 7 · 2013: 6 · 2012: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Health (MH087857)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- antioxidants, oxidative stress, neuropsychiatric disorders, schizophrenia, bipolar disorder, major depressive disorder, reactive oxygen species, antioxidant supplementation, polyunsaturated fatty acids, lipid peroxidation, DNA damage, neuroprotection
- MeSH terms
- Animals, Antioxidants, Mental Disorders, Brain, Free Radicals, Humans, Reactive Oxygen Species, Oxidative Stress
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