Cited by 26Hydrogels: synthesis, properties, applicationsIntestinal and Peritoneal AdhesionsCollagen: Extraction and Characterization

Development of carboxymethyl cellulose/gelatin hybrid hydrogels via radiation-induced cross-linking as novel anti-adhesion barriers

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Swilem, Ahmed E., Oyama, Tomoko Gowa, Oyama, Kotaro, Kimura, Atsushi, Taguchi, Mitsumasa·2022·Polymer Degradation and Stability

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Crossref · 10.1016/j.polymdegradstab.2022.109856

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2 of 2 references verified0 citation errors · 0 not checkable

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  • The CMC component of CMC-gelatin hydrogels effectively reduced fibroblast adhesion, while gelatin supported the viability of limited attached cells.

    “The CMC component effectively reduced fibroblast adhesion, while gelatin supported the viability of limited attached cells.”
  • If not fully absorbed, residual CMC may interfere with tissue remodeling.

    “If not fully absorbed, residual CMC may interfere with tissue remodeling [141].”
  • Enzymatic degradation tests confirmed that gelatin content enabled controlled biodegradation of CMC-gelatin hydrogels, modulated by radiation dose.

    “Moreover, enzymatic degradation tests confirmed that gelatin content enabled controlled biodegradation, modulated by radiation dose.”
  • In a recent study, a CMC-gelatin hybrid hydrogel crosslinked via γ-radiation at a 60:40 CMC-to-gelatin ratio achieved compressive moduli between 20 and 100 kPa, closely mimicking abdominal tissue mechanics.

    “This formulation, particularly at a 60:40 CMC-to-gelatin ratio, achieved compressive moduli between 20 and 100 kPa, closely mimicking abdominal tissue mechanics.”
  • CMC-gelatin hydrogels showed reduced foreign body response and strong anti-adhesive properties.

    “These hydrogels also showed reduced foreign body response and strong anti-adhesive properties, highlighting their potential as biocompatible, tunable barrier materials for postoperative adhesion prevention (Figure 7B) [141].”

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Authors
Swilem, A. E., Oyama, T. G., Oyama, K., Kimura, A., & Taguchi, M.
Affiliations
  • Ain Shams University (EG)
  • National Institutes for Quantum Science and Technology (JP)
Corresponding author
Taguchi, Mitsumasa
Venue
Polymer Degradation and Stability
Publisher
Elsevier BV
Published
2022-03
Volume
197
Pages
109856
ISSN
0141-3910 (ISSN-L)
OpenAlex
W4212998256
Cited by
26
References
2
Citations by year
2026: 4 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 4
FWCI
1.77
Type
journal article
Language
en
Open access
Locations
  • Polymer Degradation and Stability (acceptedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
  • QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion, cc-by-nc-nd)
Funders
Japan Society for the Promotion of Science (19K12653)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Keywords
carboxymethyl cellulose, gelatin, hybrid hydrogels, anti-adhesion barrier, postoperative adhesions, gamma irradiation crosslinking, foreign body reaction, compressive modulus, hydrogel degradation, cell adhesion, 3T3 fibroblasts, wound healing, abdominal surgery

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