Development of carboxymethyl cellulose/gelatin hybrid hydrogels via radiation-induced cross-linking as novel anti-adhesion barriers
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The CMC component of CMC-gelatin hydrogels effectively reduced fibroblast adhesion, while gelatin supported the viability of limited attached cells.
“The CMC component effectively reduced fibroblast adhesion, while gelatin supported the viability of limited attached cells.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [141]
If not fully absorbed, residual CMC may interfere with tissue remodeling.
“If not fully absorbed, residual CMC may interfere with tissue remodeling [141].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [141]
Enzymatic degradation tests confirmed that gelatin content enabled controlled biodegradation of CMC-gelatin hydrogels, modulated by radiation dose.
“Moreover, enzymatic degradation tests confirmed that gelatin content enabled controlled biodegradation, modulated by radiation dose.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [141]
In a recent study, a CMC-gelatin hybrid hydrogel crosslinked via γ-radiation at a 60:40 CMC-to-gelatin ratio achieved compressive moduli between 20 and 100 kPa, closely mimicking abdominal tissue mechanics.
“This formulation, particularly at a 60:40 CMC-to-gelatin ratio, achieved compressive moduli between 20 and 100 kPa, closely mimicking abdominal tissue mechanics.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [141]
CMC-gelatin hydrogels showed reduced foreign body response and strong anti-adhesive properties.
“These hydrogels also showed reduced foreign body response and strong anti-adhesive properties, highlighting their potential as biocompatible, tunable barrier materials for postoperative adhesion prevention (Figure 7B) [141].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [141]
Cites
Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
Carnicer-Lombarte, A., Chen, S.-T., Malliaras, G. G., & Barone, D. G. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.622524 · Cited by 454 · see citing works
Zwitterionic PEG-PC Hydrogels Modulate the Foreign Body Response in a Modulus-Dependent Manner
Jansen, L. E., Amer, L. D., Chen, E. Y.-T., Nguyen, T. V., Saleh, L. S., Emrick, T., Liu, W. F., Bryant, S. J., & Peyton, S. R. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00444 · Cited by 120 · see citing works
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Swilem, A. E., Oyama, T. G., Oyama, K., Kimura, A., & Taguchi, M.
- Affiliations
- Ain Shams University (EG)
- National Institutes for Quantum Science and Technology (JP)
- Corresponding author
- Taguchi, Mitsumasa
- Venue
- Polymer Degradation and Stability
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 197
- Pages
- 109856
- ISSN
- 0141-3910 (ISSN-L)
- OpenAlex
- W4212998256
- Cited by
- 26
- References
- 2
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 4
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 709 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Polymer Degradation and Stability (acceptedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Society for the Promotion of Science (19K12653)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- carboxymethyl cellulose, gelatin, hybrid hydrogels, anti-adhesion barrier, postoperative adhesions, gamma irradiation crosslinking, foreign body reaction, compressive modulus, hydrogel degradation, cell adhesion, 3T3 fibroblasts, wound healing, abdominal surgery
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