The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.
The prebiotic geochemistry of formaldehyde
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Formaldehyde is their most plausible prebiotic precursor,61 due to its capacity to yield a variety of carbohydrates in a one-pot process known as the formose reaction, discovered by Butlerow in 1861.62”
From The protometabolic nature of prebiotic chemistry (2023) · cites this paper as [61]
Citations
Cites
A Production of Amino Acids Under Possible Primitive Earth Conditions
Miller, S. L. (1953) · Science · doi:10.1126/science.117.3046.528 · Cited by 3,522
Gilbert, W. (1986) · Nature · doi:10.1038/319618a0 · Cited by 2,721
Gilbert, W. (1986) · Nature · Cited by 1,941
The Chemical Evolution of the Atmosphere and Oceans
Holland, H. D. (1984) · doi:10.1515/9780691220239 · Cited by 1,836
Wilde, S. A., Valley, J. W., Peck, W. H., & Graham, C. M. (2001) · Nature · doi:10.1038/35051550 · Cited by 1,744 · cited 1×
“This species may be chemically inert (Wolman et al., 1971), although there are dissenting opinions (Fox and Windsor, 1970).”
BackgroundChyba, C., & Sagan, C. (1992) · Nature · doi:10.1038/355125a0 · Cited by 1,321
Racemic amino acids from the ultraviolet photolysis of interstellar ice analogues
Bernstein, M. P., Dworkin, J. P., Sandford, S. A., Cooper, G. W., & Allamandola, L. J. (2002) · Nature · doi:10.1038/416401a · Cited by 800
Borate Minerals Stabilize Ribose
Ricardo, A., Carrigan, M. A., Olcott, A. N., & Benner, S. A. (2004) · Science · doi:10.1126/science.1092464 · Cited by 646
Cometary Delivery of Organic Molecules to the Early Earth
Chyba, C. F., Thomas, P. J., Brookshaw, L., & Sagan, C. (1990) · Science · doi:10.1126/science.11538074 · Cited by 577
Carbonaceous meteorites as a source of sugar-related organic compounds for the early Earth
Cooper, G., Kimmich, N., Belisle, W., Sariñana, J., Brabham, K., & Garrel, L. (2001) · Nature · doi:10.1038/414879a · Cited by 496
Cited by
Sorted by citations
Items 101–179 of 179
Ranjan, S., Abdelazim, K., Lozano, G. G., Mandal, S., Zhou, C. Y., Kufner, C. L., Todd, Z. R., Sahai, N., & Sasselov, D. D. (2023) · AGU Advances · doi:10.1029/2023av000926 · Cited by 12
Takabayashi, M., Hirakawa, Y., Kakegawa, T., & Furukawa, Y. (2023) · GEOCHEMICAL JOURNAL · doi:10.2343/geochemj.gj23012 · Cited by 9
Radicals in Prebiotic Chemistry
Lim, R. W. J., & Fahrenbach, A. C. (2020) · Pure and Applied Chemistry · doi:10.1515/pac-2020-0805 · Cited by 8
Benner, S. A., Kim, H.-J., & Biondi, E. (2018) · Nucleic Acids and Molecular Biology · doi:10.1007/978-3-319-93584-3_3 · Cited by 10
Zeffiro, A., Lazzaroni, S., Merli, D., Profumo, A., Buttafava, A., Serpone, N., & Dondi, D. (2015) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-015-9479-5 · Cited by 8
Bourgalais, J., Carrasco, N., Miguel, Y., Vénot, O., & Pernot, P. (2021) · Astronomy and Astrophysics · doi:10.1051/0004-6361/202141328 · Cited by 8
Enigmatic Issues and Widening Implications of Research on Martian Clay Minerals
Zhong, J. Q., Fiore, S., Chen, X. X., & Zhou, C. H. (2022) · ACS Earth and Space Chemistry · doi:10.1021/acsearthspacechem.2c00091 · Cited by 8
Non‐enzymatic Ribonucleotide Reduction in the Prebiotic Context
Dragičević, I., Barić, D., Kovačević, B., Golding, B. T., & Smith, D. M. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201405741 · Cited by 9
Decomposition pathways of formamide in the presence of vanadium and titanium monoxides
Nguyen, H. T., & Nguyen, M. T. (2015) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp01456e · Cited by 7
New dithiazinanes and bis‐dithiazinanes‐bearing pendant ethylamines: Structure and reactivity
Colorado‐Peralta, R., Lopez-Rocha, C. A., Sánchez-Ruíz, S. A., Contreras, R., & Flores‐Parra, A. (2010) · Heteroatom Chemistry · doi:10.1002/hc.20657 · Cited by 7
Database on mineral mediated carbon reduction: implications for future research
Prakash, M., Weber, J. M., Rodriguez, L. E., Sheppard, R. Y., & Barge, L. M. (2022) · International Journal of Astrobiology · doi:10.1017/s1473550422000052 · Cited by 6
Shtyrlin, V. G., Borissenok, V. A., Serov, N. Y., Геннадиевич, С. В., Алексеевич, Б. В., Трунин, И. Р., Tereshkina, I. A., Кошкин, С. А., Bukharov, M. S., Gilyazetdinov, E. M., et al. (2019) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-019-09575-8 · Cited by 6
Ribose Accumulation in Borate-Rich Prebiotic Environments
Takahashi, Y., Kim, H.-J., Benner, S. A., Kakegawa, T., & Furukawa, Y. (2026) · Astrobiology · doi:10.1177/15311074261417882 · Cited by 5
Exploring Free Energy Profiles of Uracil and Cytosine Reactions with Formaldehyde
Kua, J. (2019) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.9b02105 · Cited by 4
Edri, R., Joshi, M. P., Frenkel‐Pinter, M., Hud, N. V., Keating, C. D., & Leman, L. J. (2025) · Astrobiology · doi:10.1177/15311074251365943 · Cited by 5
On the Ability of Formaldehyde to Act as a Tethering Catalyst in Water
Jamshidi, M. P., Macdonald, M., & Beauchemin, A. M. (2017) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-017-9538-1 · Cited by 4
Scope and limitations of two model prebiotic routes to tetrapyrrole macrocycles
Taniguchi, M., Deans, R. M., Chandrashaker, V., Ptaszek, M., & Lindsey, J. S. (2016) · New Journal of Chemistry · doi:10.1039/c6nj01423b · Cited by 4
The Origin of the Feedstock Molecules for Life on the Hadean Earth
Diukarev, N., Boinowitz, E., Feldmann, J., Wiedemann, S., Mikheev, A. S., Becker, S. M., & Carell, T. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202512374 · Cited by 8
Sugar-Driven Prebiotic Synthesis of Ammonia from Nitrite
Weber, A. L. (2010) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-010-9208-z · Cited by 3
Spontaneous Oligomerization of Nucleotide Alternatives in Aqueous Solutions
Smith, K. E., House, C. H., Dworkin, J. P., & Callahan, M. P. (2016) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-016-9484-3 · Cited by 3
Mathanlal, T., Bhardwaj, A., Ramachandran, A. V., Zorzano, M., Martín‐Torres, J., & Cockell, C. S. (2021) · International Journal of Astrobiology · doi:10.1017/s1473550420000385 · Cited by 3
Multiverse Predictions for Habitability: Origin of Life Scenarios
Sandora, M., Airapetian, V., Barnes, L. A., Lewis, G. F., & Pérez‐Rodríguez, I. (2023) · Universe · doi:10.3390/universe9010042 · Cited by 3
Clairmont, R. M., Bommarius, A. S., & Weber, A. L. (2015) · Journal of Molecular Evolution · doi:10.1007/s00239-015-9687-7 · Cited by 3
Reakcija formoze – sveti gral kemičara
Institut za medicinska istraživanja i medicinu rada, K. C. 2., & Raos, N. (2018) · Kemija u industriji · doi:10.15255/kui.2017.020 · Cited by 3
The Origin of RNA and the Formose–Ribose–RNA Pathway
Bánfalvi, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126727 · Cited by 3
Colorado‐Peralta, R., & Flores‐Parra, A. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216038 · Cited by 2
Fuentes-Carreón, C. A., Meléndez-López, A. L., Cruz-Castañeda, J. A., & Negrón-Mendoza, A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36227 · Cited by 2
Origin of homochirality in peptides: The first milestone at the origin of life
Toxværd, S. (2025) · Biosystems · doi:10.1016/j.biosystems.2025.105479 · Cited by 2
Experimental Models on the Prebiotic Formation of Biopolymer Building Blocks
Menor-Salván, C., & Ruiz‐Bermejo, M. (2025) · Astrobiology · doi:10.1177/15311074251365950 · Cited by 5
An Aminoisoxazole‐Based Proto‐RNA
Xu, F., Wiedemann, S., Feldmann, J., Becker, S. M., & Carell, T. (2023) · ChemistryEurope · doi:10.1002/ceur.202300057 · Cited by 2
Rinaldi, G., Salta, Z., & Tasinato, N. (2024) · ACS Earth and Space Chemistry · doi:10.1021/acsearthspacechem.4c00302 · Cited by 2
A prebiotic photochemical synthesis of glycerides
Aylward, N. (2009) · Cited by 2
The Origin and Early Evolution of Life: Prebiotic Chemistry of Biomolecules
Fiore, M. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-607-9 · Cited by 2
Coenzyme und ihre Rolle in der Evolution des Lebens
Kirschning, A. (2020) · Angewandte Chemie · doi:10.1002/ange.201914786 · Cited by 3
Prebiotic Chemistry in the Wild: How Geology Interferes with the Origins of LifePreprint
Walton, C. R., Rimmer, P. B., Williams, H., & Shorttle, O. (2020) · ChemRxiv · doi:10.26434/chemrxiv.13198205.v1 · Cited by 3
Springsteen, G. (2014) · Encyclopedia of Astrobiology · doi:10.1007/978-3-642-27833-4_722-2 · Cited by 2
Thuan, J. C., Koirala, A., Pirez, J., & Ohata, J. (2025) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.5c00167 · Cited by 2
Camprubí, E., Pearce, B. K. D., & Preiner, M. (2026) · Astrobiology · doi:10.1177/15311074261454245 · Cited by 1
Radiation-induced reactions in comet analogues
López-Islas, A., & Negrón-Mendoza, A. (2022) · International Journal of Astrobiology · doi:10.1017/s1473550422000416 · Cited by 1
Zhang, Z., Jiang, H.-F., Ju, P., Pan, L., Rouillard, J., Zhou, G., Huang, F., & Hao, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1032073 · Cited by 2
Prebiotic Photoredox Synthesis from Carbon Dioxide and SulfitePreprint
Liu, Z., Wu, L.-F., Kufner, C. L., Sasselov, D. D., Fischer, W. W., & Sutherland, J. (2021) · ChemRxiv · doi:10.26434/chemrxiv.13692772 · Cited by 3
Peng, Z., Linderoth, J., & Baum, D. (2021) · ChemRxiv · doi:10.26434/chemrxiv-2021-1nj64-v3 · Cited by 1
Peng, Z., Linderoth, J., & Baum, D. (2021) · doi:10.33774/chemrxiv-2021-1nj64-v3 · Cited by 1
Springsteen, G. (2015) · Encyclopedia of Astrobiology · doi:10.1007/978-3-662-44185-5_722 · Cited by 1
Prebiotic Chemistry in the Wild: How Geology Interferes with the Origins of LifePreprint
Walton, C. R., Rimmer, P. B., Williams, H., & Shorttle, O. (2020) · ChemRxiv · doi:10.26434/chemrxiv.13198205 · Cited by 2
Peng, Z., Linderoth, J., & Baum, D. (2021) · doi:10.33774/chemrxiv-2021-1nj64 · Cited by 1
Springsteen, G. (2023) · Encyclopedia of Astrobiology · doi:10.1007/978-3-662-65093-6_722 · Cited by 1
"Avaliação da Exposição Profissional ao Formaldeído: Efeito Genotóxico".
Piña, C. (2011) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/7rme-n384
Habitability, Effects of Stellar Irradiation
Kaltenegger, L. (2015) · Encyclopedia of Astrobiology · doi:10.1007/978-3-662-44185-5_488
Peng, Z., Linderoth, J., & Baum, D. (2021) · doi:10.33774/chemrxiv-2021-1nj64-v2
The Geological Platform for the Origin of Life on Earth
Stüeken, E. E., & Gardiner, N. J. (2021) · Advances in astrobiology and biogeophysics · doi:10.1007/978-3-030-81039-9_3
Peng, Z., Linderoth, J., & Baum, D. (2021) · doi:10.33774/chemrxiv-2021-1nj64-v4
Cleaves, H. J. (2015) · Encyclopedia of Astrobiology · doi:10.1007/978-3-662-44185-5_585
Peng, Z., Linderoth, J., & Baum, D. (2021) · ChemRxiv · doi:10.26434/chemrxiv-2021-1nj64-v2
Peng, Z., Linderoth, J., & Baum, D. (2021) · ChemRxiv · doi:10.26434/chemrxiv-2021-1nj64
Cleaves, H. J. (2014) · Encyclopedia of Astrobiology · doi:10.1007/978-3-642-27833-4_585-3
Cleaves, H. J. (2022) · Encyclopedia of Astrobiology · doi:10.1007/978-3-642-27833-4_585-4
Cleaves, H. J. (2023) · Encyclopedia of Astrobiology · doi:10.1007/978-3-662-65093-6_585
Addressing the Miller Paradox and the Prebiotic Synthesis of Nucleobases
Callahan, M. P., & Cleaves, H. J. (2023) · ACS Earth and Space Chemistry · doi:10.1021/acsearthspacechem.3c00246
Cruz-Simbrón, R., Sharma, S., Arya, A., Ray, J., Lozano, A., Andersen, J. L., Chen, H., & Cleaves, H. J. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-nj0p6
Cruz-Simbrón, R., Sharma, S., Arya, A., Ray, J., Lozano, A., Andersen, J. L., Chen, H., & Cleaves, H. J. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-nj0p6-v2
Milestones at the Origin of LifePreprint
Toxværd, S. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5162691
Aylward, N. (2025) · MOLECULAR SCIENCES AND APPLICATIONS · doi:10.37394/232023.2025.5.6
Zhang, W., Zhao, S., & Serianni, A. S. (2025) · ACS Earth and Space Chemistry · doi:10.1021/acsearthspacechem.5c00097
Der Ursprung der Bausteine des Lebens auf der Erde im Hadaikum
Diukarev, N., Boinowitz, E., Feldmann, J., Wiedemann, S., Mikheev, A. S., Becker, S. M., & Carell, T. (2025) · Angewandte Chemie · doi:10.1002/ange.202512374
Conserved-Potential-Driven Molecular Dynamics Deciphers Formose Reaction Mechanisms
Kan, H. W., Li, X.-T., Zhu, T., Xu, Y., & Zhang, J. Z. H. (2026) · JACS Au · doi:10.1021/jacsau.5c01359 · Cited by 1
Braam, M., Gopaoco, E., Tsai, S., Friss, G., Palmer, P. I., Rimmer, P. B., & White (2026) · Icarus · doi:10.1016/j.icarus.2026.117032 · Cited by 1
Abiotic CO2 reduction promoted by carbonate and phyllosilicate minerals on the primitive seafloor
Zhong, Y., Zhang, N., Huan, D., Low, J., Daniel, I., Cleaves, H. J., Zhang, C., Li, Y., Jiang, Y., Wang, X., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71130-7
Wang, S., Yang, Z., Li, H., He, C., Wang, Y., Luo, X., Liu, Y., Hörst, S. M., Moran, S. E., Vuitton, V., et al. (2026) · Astronomy and Astrophysics · doi:10.1051/0004-6361/202658994
Endo, Y., Watanabe, Y., & Ozaki, K. (2026) · The Astrophysical Journal · doi:10.3847/1538-4357/ae6266
The RNA World Hypothesis: A Critical Reassessment of Prebiotic Plausibility
Truman, R. J. (2026) · BioCosmos · doi:10.2478/biocosmos-2026-0003
Fuentes-Carreón, C. A., de la Rosa, J., & Cruz-Castañeda, J. A. (2026) · Life Sciences in Space Research · doi:10.1016/j.lssr.2026.05.005
On the timing of eukaryotic origin
Song, N., Pang, K., Feng, X., & Li, M. (2026) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1002/brv.70201
Anand, M., van der Bogert, C. H., Batty, C. A., Crawford, I., Onofri, S., Paiva, F. S., Pearce, D. A., Reiss, P., L’Haridon, J., Stephant, A., et al. (2026) · Advances in Space Research · doi:10.1016/j.asr.2026.08.047
LaRowe, D. E. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7351049
Chemical Pathways to the Origin of Life
Zhu, S., & Liu, T. (2026) · Chinese Journal of Organic Chemistry · doi:10.6023/cjoc202605021
Intimate Link Between Prebiotic Chemistry and Meteorites: Mechanisms of Organic Molecule Formation
Tunney, L. D., Harrison, P. H. M., & Slater, G. F. (2026) · Astrobiology · doi:10.1177/15311074261493342
LaRowe, D. E. (2026) · Carbohydrate Research · doi:10.1016/j.carres.2026.110136
Metadata
- Authors
- Cleaves II, H. J.
- Venue
- Precambrian Research
- Publisher
- Elsevier BV
- Published
- 2008-07-30
- Volume
- 164
- Issue
- 3-4
- Pages
- 111-118
- ISSN
- 0301-9268 (ISSN-L)
- OpenAlex
- W2088227558
- Cited by
- 179
- References
- 101
- Citations by year
- 2026: 15 · 2025: 11 · 2024: 12 · 2023: 17 · 2022: 8 · 2021: 20 · 2020: 20 · 2019: 10 · 2018: 12 · 2017: 6 · 2016: 7 · 2015: 15 · 2014: 3 · 2013: 11 · 2012: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Precambrian Research (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Paleontology and Stratigraphy of Fossils
- Physical Sciences › Earth and Planetary Sciences › Space and Planetary Science › Astro and Planetary Science
- Keywords
- formaldehyde, origin of life, ribose synthesis, Strecker synthesis, amino acid synthesis, sugar synthesis, hydrothermal environments, photolysis, extraterrestrial organic matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review