Sleep Disturbances in Patients with Medical Conditions
Abstract
Sleep-wake cycle disturbances are prevalent in patients with medical conditions and frequently present as part of a symptom cluster. Sleep disturbances impair functioning and quality of life, decrease adherence to treatments of the primary medical condition, and increase morbidity and mortality. The pathophysiology of sleep disturbances in these patients involves alterations in immune and neuroendocrine function and shares common pathophysiologic pathways with comorbidities such as fatigue and depression. Emphasis is placed on the evaluation and management of medical and psychiatric comorbidities and other factors contributing to sleep problems. Primary treatments include cognitive-behavioral therapy and pharmacotherapy.
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A study in healthy humans found that CSF levels of amyloid beta, a DAMP that is released during synaptic firing, showed a rhythm parallel to the sleep-wake cycle (amyloid beta increases during the day and decreases overnight).
“a study in healthy humans found that CSF levels of amyloid beta, a DAMP (115) that is released during synaptic firing, showed a rhythm parallel to the sleep-wake cycle (i.e., amyloid beta increases during the day and decreases overnight)”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [280]
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References 89 · Cited by 21
- Authors
- Kamath, J., Prpich, G., & Jillani, S.
- Affiliations
- University of Connecticut (US)
- Corresponding author
- Kamath, Jayesh
- ORCID
- Kamath, Jayesh
- Venue
- Psychiatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 38
- Issue
- 4
- Pages
- 825-841
- ISSN
- 0193-953X (ISSN-L)
- OpenAlex
- W1149814848
- Cited by
- 21
- References
- 89
- Citations by year
- 2025: 5 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep disorders, sleep-wake cycle, comorbidities, psychiatric comorbidity, fatigue, depression, immune function, neuroendocrine function, medication adherence, quality of life, cognitive behavioral therapy, pharmacotherapy
- MeSH terms
- Combined Modality Therapy, Humans, Neoplasms, Nervous System Diseases, Pain, Risk Factors, Sleep Wake Disorders, Disease Management
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