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Cited by 133Transcranial Magnetic Stimulation StudiesNeurotransmitter Receptor Influence on BehaviorNeurological disorders and treatments

Acute prefrontal rTMS increases striatal dopamine to a similar degree as D-amphetamine

Pogarell, Oliver, Koch, Walter, Pöpperl, Gabriele, Tatsch, Klaus, Jakob, Franziska, Mulert, Christoph, Grossheinrich, Nicola, Rupprecht, Rainer +3 more·2007·Psychiatry Research Neuroimaging
DOI 10.1016/j.pscychresns.2007.05.002
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Abstract

Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been shown to increase striatal dopaminergic activity. Here we investigated dopaminergic neurotransmission using single photon emission computed tomography (SPECT) and [(123)I]IBZM to indirectly assess the change in endogenous striatal dopamine concentration upon rTMS as compared with d-amphetamine challenge. SPECT imaging was performed twice each in five patients during rTMS, and in two patients who received 0.3 mg/kg D-amphetamine. Administration of rTMS led to a mean relative decrease in striatal IBZM binding by 9.6+/-6.2%, and d-amphetamine challenge (n=4) induced a mean relative reduction by 8+/-2.95% (difference not statistically significant). Acute rTMS challenge showed similar striatal dopaminergic effects to those associated with the administration of d-amphetamine, a substance known to increase synaptic dopamine.

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Crossref · 10.1016/j.pscychresns.2007.05.002

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  • Prefrontal stimulation has been shown to increase striatal dopamine, similar to amphetamines, which is typically reduced in ADHD.

    “prefrontal stimulation has shown to increase striatal dopamine (Pogarell et al., 2007), similar to amphetamines, which is typically reduced in ADHD (Fusar-Poli et al., 2012).”

    From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Pogarell et al., 2007

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References 18 · Cited by 133

Authors
Pogarell, O., Koch, W., Pöpperl, G., Tatsch, K., Jakob, F., Mulert, C., Grossheinrich, N., Rupprecht, R., Möller, H.-J., Hegerl, U., & Padberg, F.
Affiliations
Ludwig-Maximilians-Universität München (DE)
Corresponding author
Koch, Walter
ORCID
Venue
Psychiatry Research Neuroimaging
Publisher
Elsevier BV
Published
2007-12
Volume
156
Issue
3
Pages
251-255
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2007.05.002
OpenAlex
W2004731697
Cited by
133
References
18
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 20 · 2022: 14 · 2021: 9 · 2020: 12 · 2019: 3 · 2018: 8 · 2017: 10 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 5
FWCI
2.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
repetitive transcranial magnetic stimulation, prefrontal cortex, striatal dopamine, d-amphetamine, dopamine release, dopamine signaling, single photon emission computed tomography
MeSH terms
Central Nervous System Stimulants, Benzamides, Corpus Striatum, Major Depressive Disorder, Dextroamphetamine, Female, Humans, Injections, Intravenous, Iodine Radioisotopes, Male, Middle Aged, Pyrrolidines, Tomography, Emission-Computed, Single-Photon, Prefrontal Cortex, Transcranial Magnetic Stimulation

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