Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder
Open accessAbstract
Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.
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Resting-state amygdala connectivity has been reported to be altered in individuals with generalized anxiety disorder, social phobia, major depressive disorder and bipolar disorder.
“it has been reported to be altered in individuals with generalized anxiety disorder (GAD),39 social phobia,40 major depressive disorder (MDD)41,42 and bipolar disorder;43”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [43]
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References 51 · Cited by 175
- Authors
- Chepenik, L. G., Raffo, M., Hampson, M., Lacadie, C., Wang, F., Jones, M. M., Pittman, B., Skudlarski, P., & Blumberg, H. P.
- Affiliations
- Yale University (US)
- Corresponding author
- Chepenik, Lara G.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 182
- Issue
- 3
- Pages
- 207-210
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC2914819
- OpenAlex
- W2017090298
- Cited by
- 175
- References
- 51
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 28 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 11 · 2015: 8 · 2014: 22 · 2013: 16 · 2012: 24
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Department of Veterans Affairs Research Career Development
- Merit Review
- Research Enhancement Award Program (REAP) Awards
- National Institute of Mental Health (R01MH070902, T32MH14276)
- National Alliance for Research on Schizophrenia and Depression (Great Neck, NY)
- Attias Family Foundation
- Ethel F. Donaghue Women's Investigator Program at Yale (New Haven, CT)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- bipolar disorder, ventral prefrontal cortex, amygdala, functional connectivity, resting state, ventral striatum, interhemispheric connectivity
- MeSH terms
- Adolescent, Adult, Amygdala, Bipolar Disorder, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Oxygen, Rest, Prefrontal Cortex, Young Adult
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