Impaired mismatch negativity is associated with current functional status rather than genetic vulnerability to schizophrenia
Abstract
The aim of this study is to investigate whether mismatch negativity (MMN) is associated with functional status or is a state-independent trait for schizophrenia. We assessed MMN in 26 patients with schizophrenia, 20 healthy subjects with high genetic loading, and 48 healthy controls. Repeated measures analysis of variance and Pearson׳s correlations were used to test the hypothesis that MMN is not state-independent. We found a significant main effect of group, indicating differences in the peak amplitudes of the MMN among the three groups. Post-hoc analyses revealed that schizophrenia patients showed a significant reduction in the peak amplitude of MMN, but subjects at high genetic risk and healthy controls did not. Additionally, significant correlations between Global Assessment of Functioning scores and MMN peak amplitude at Fz and Cz were found in patients with schizophrenia. These findings suggest that MMN may reflect current functional status rather than a genetic risk for schizophrenia.
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Reduced MMN amplitude is not associated with genetic vulnerability.
“Reduced MMN amplitude is associated with cognitive impairments and poor functional outcomes (7), but not associated with genetic vulnerability (8).”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [8]
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References 44 · Cited by 46
- Authors
- Kim, M., Kim, S. N., Lee, S., Byun, M. S., Shin, K. S., Park, H. Y., Jang, J. H., & Kwon, J. S.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kwon, Jun Soo
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 222
- Issue
- 1-2
- Pages
- 100-106
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W1983248675
- Cited by
- 46
- References
- 44
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 8 · 2019: 13 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 3 · 2013: 1
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- mismatch negativity, schizophrenia, functional status, genetic susceptibility, genetic risk, Global Assessment of Functioning, event-related potentials, state independence
- MeSH terms
- Adult, Brain, Brain Mapping, Electroencephalography, Evoked Potentials, Female, Humans, Male, Schizophrenia, Schizophrenic Psychology, Young Adult
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