Markers of neuroinflammation influence measures of cortical thickness in bipolar depression
Abstract
We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.
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In patients with a depressive episode in major depressive disorder or bipolar disorder, peripheral levels of IL-8, TNF-α, CCL2, and CCL4 are associated with cortical thickness.
“In patients with a depressive episode in course of Major Depressive Disorder (MDD) or Bipolar Disorder (BD), we have previously reported an association of peripheral IL-8, TNF-α, CCL2, CCL4 with cortical thickness (Poletti et al., 2019)”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Poletti et al., 2019
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References 20 · Cited by 54
- Authors
- Poletti, S., Leone, G., Hoogenboezem, T. A., Ghiglino, D., Vai, B., de Wit, H., Wijkhuijs, A. J. M., Locatelli, C., Colombo, C., Drexhage, H. A., & Benedetti, F.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- IRCCS Ospedale San Raffaele (IT)
- Erasmus MC (NL)
- Corresponding author
- Poletti, Sara
- ORCID
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 285
- Pages
- 64-66
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2913921923
- Cited by
- 54
- References
- 20
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 12 · 2022: 6 · 2021: 12 · 2020: 10 · 2019: 3
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuroinflammation, bipolar depression, cortical thickness, cytokines, chemokines, gray matter volume, inferior temporal gyrus, parahippocampal gyrus, anterior cingulate cortex, BOLD signal, negative stimuli, ICAM-1, carbon tetrachloride, soluble interleukin-2 receptor, TNF-α, interleukin-8, MCP-1, immune activation
- MeSH terms
- Adult, Bipolar Disorder, Decision Making, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Biomarkers, Inflammation Mediators, Young Adult
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