Spatial covariance analysis of FDG-PET and HMPAO-SPECT for the differential diagnosis of dementia with Lewy bodies and Alzheimer's disease
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Abstract
We investigated diagnostic characteristics of spatial covariance analysis (SCA) of FDG-PET and HMPAO-SPECT scans in the differential diagnosis of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), in comparison with visual ratings and region of interest (ROI) analysis. Sixty-seven patients (DLB 29, AD 38) had both HMPAO-SPECT and FDG-PET scans. Spatial covariance patterns were used to separate AD and DLB in an initial derivation group (DLB n=15, AD n=19), before being forward applied to an independent group (DLB n=14, AD n=19). Visual ratings were by consensus, with ROI analysis utilising medial occipital/medial temporal uptake ratios. SCA of HMPAO-SPECT performed poorly (AUC 0.59±0.10), whilst SCA of FDG-PET (AUC 0.83±0.07) was significantly better. For FDG-PET, SCA showed similar diagnostic performance to ROI analysis (AUC 0.84±0.08) and visual rating (AUC 0.82±0.08). In contrast to ROI analysis, there was little concordance between SCA and visual ratings of FDG-PET scans. We conclude that SCA of FDG-PET outperforms that of HMPAO-SPECT. SCA of FDG-PET also performed similarly to the other analytical approaches, despite the limitations of a relatively small SCA derivation group. Compared to visual rating, SCA of FDG-PET relies on different sources of group variance to separate DLB from AD.
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Using spatial covariance analysis of FDG-PET data, Ingram et al. discriminated AD from DLB with an AUC of 0.84.
“Using spatial covariance analysis of FDG-PET data, Ingram et al. were able to discriminate AD from DLB with an AUC of 0.84 [124].”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [124]
Cites
Dementia with Lewy bodies: Basis of cingulate island sign
Graff-Radford, J., Murray, M. E., Lowe, V. J., Boeve, B. F., Ferman, T. J., Przybelski, S. A., Lesnick, T. G., Senjem, M. L., Gunter, J. L., Smith, G. E., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000734 · Cited by 163 · see citing works
Multivariate data analysis for neuroimaging data: overview and application to Alzheimer’s disease
Initiative, T. A. D. N., Habeck, C., & Stern, Y. (2010) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-010-9093-0 · Cited by 127 · see citing works
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The use of neuroimaging techniques in the early and differential diagnosis of dementia
Chouliaras, L., & O’Brien, J. T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02215-8 · Cited by 186 · see citing works
Self-citation
- Authors
- Ingram, M., Colloby, S. J., Firbank, M. J., Lloyd, J. J., O'Brien, J. T., & Taylor, J.-P.
- Affiliations
- Newcastle University (GB)
- University of Cambridge (GB)
- Corresponding author
- Ingram, Matthew
- ORCID
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 322
- Pages
- 111460
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W4220957256
- Cited by
- 9
- References
- 2
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 3 · 2022: 1
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- medRxiv (acceptedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- National Institute for Health and Care Research (PB-PG-1207-13105)
- University of Cambridge
- Newcastle University
- Cambridge University Hospitals
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- Research for Patient Benefit Programme
- NIHR Newcastle Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- dementia with Lewy bodies, Alzheimer's disease, differential diagnosis, FDG-PET, HMPAO SPECT, brain glucose metabolism, brain perfusion imaging, visual rating, region of interest analysis
- MeSH terms
- Alzheimer Disease, Diagnosis, Differential, Humans, Tomography, Emission-Computed, Single-Photon, Fluorodeoxyglucose F18, Lewy Body Disease, Positron-Emission Tomography
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