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Cited by 218Treatment of Major DepressionTryptophan and brain disordersTrace Elements in Health

Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder—A postmortem study

Michel, Tanja Maria, Frangou, Sophia, Thiemeyer, Dorothea, Camara, Sibylle, Jecel, Julia, Nara, Keinosuke, Brunklaus, Andreas, Zoechling, Robert +1 more·2007·Psychiatry Research
DOI 10.1016/j.psychres.2006.04.013
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Abstract

Prefrontal cortical (PFC) and hippocampal (HI) volume reductions have been consistently found in patients with recurrent depressive disorder (DD). Here we examine the possibility that oxidative stress, widely implicated in neuronal cell damage, may contribute to these brain structural changes. We compared manganese (Mn) and copper/zinc (Cu/Zn) superoxide dismutase (SOD) coenzyme concentrations in postmortem PFC and hippocampal brain tissue from 7 patients with DD and 7 neuropsychiatrically healthy controls using sandwich-type enzyme-linked immunosorbent assay (ELISA) technique. The concentration of Cu/Zn-SOD was significantly increased in the PFC but not in the hippocampus of patients. There was no significant change in Mn-SOD enzyme concentration in either region. Our findings contribute to the growing body of evidence implicating oxidative stress in the pathophysiology of depressive disorder.

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  • In major depressive disorder, higher oxidative stress, lower antioxidants, and oxidant-antioxidant imbalance are well documented in the hippocampus and medial prefrontal cortex, along with markers of DNA/RNA damage.

    “increased oxidative stress, lower antioxidant levels, and imbalanced oxidant:antioxidant levels have been well documented within the hippocampus (103,104) and mPFC (104–106), resulting in associated markers of DNA/RNA damage in these regions.”

    From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [105]

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References 43 · Cited by 218

Authors
Michel, T. M., Frangou, S., Thiemeyer, D., Camara, S., Jecel, J., Nara, K., Brunklaus, A., Zoechling, R., & Riederer, P.
Affiliations
  • Universitätsklinikum Würzburg (DE)
  • SHOWA Medical University (JP)
  • Guy's Hospital (GB)
Corresponding author
Michel, Tanja Maria
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2007-05
Volume
151
Issue
1-2
Pages
145-150
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2006.04.013
OpenAlex
W2028274535
Cited by
218
References
43
Citations by year
2026: 7 · 2025: 12 · 2024: 12 · 2023: 12 · 2022: 9 · 2021: 12 · 2020: 6 · 2019: 8 · 2018: 13 · 2017: 14 · 2016: 17 · 2015: 12 · 2014: 15 · 2013: 11 · 2012: 10
FWCI
8.64
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
oxidative stress, recurrent depression, depression, frontal cortex, hippocampus, manganese superoxide dismutase, copper-zinc superoxide dismutase, postmortem brain, neuronal injury, brain structural changes
MeSH terms
Aged, Aged, 80 and over, Depressive Disorder, Enzyme-Linked Immunosorbent Assay, Female, Frontal Lobe, Hippocampus, Humans, Male, Middle Aged, Recurrence, Superoxide Dismutase, Prefrontal Cortex, Oxidative Stress

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