Cognitive predictors of treatment response to bupropion and cognitive effects of bupropion in patients with major depressive disorder
Abstract
Cognitive effects of antidepressants and cognitive predictors of antidepressant treatment response are recent focuses of interest in the neuropsychology of depression. We studied the cognitive predictors of treatment response to bupropion and its neuropsychological effects in patients with major depressive disorder. Twenty subjects meeting the DSM-IV criteria for major depressive disorder were assessed with the Hamilton Depression Rating Scale and a neuropsychological battery. Subjects were medicated with 150 mg/day of bupropion sustained release for 8 weeks. At the end of the trial, 12 subjects were classified as responders to treatment and 8 were non-responders. Our findings suggest that low pretreatment measures of visual memory and low levels of mental processing speed are predictive of good response to bupropion. The cognitive effects of bupropion after the treatment showed that patients improved in visual memory measures and in mental processing speed. Our results suggest that cognitive predictors of treatment response to bupropion and cognitive effects of bupropion in patients with major depressive disorder could be closely related. These findings need to be replicated due to the exploratory nature of the present work.
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Some pilot studies show that cognitive deficits in major depressive disorder patients may predict non-response to treatment with selective serotonin reuptake inhibitors or dual serotonergic-noradrenergic reuptake inhibitors.
“Furthermore, some pilot studies show that cognitive deficits in MDD patients may predict non-response to treatment with selective serotonin reuptake inhibitors (SSRIs) or dual serotonergic-noradrenergic reuptake inhibitors (SNRIs), indicating that poor performance in selected cognitive domains may define a patient subgroup that requires complex or additional treatment [21–23].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [23]
Lower pretreatment performance on visual memory and processing speed tasks predicts better treatment response to bupropion in adults with major depressive disorder.
“For instance, a small study that enrolled adults with MDD (n = 20) evaluated the effects of 8 weeks of bupropion treatment (150 mg/day) on cognitive performance and reported that lower pretreatment performance on visual memory and processing speed tasks predicts better treatment response [23], supporting the hypothesis that depressed patients with psychomotor slowing may show greater response to”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [23]
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References 54 · Cited by 78
- Authors
- Herrera-Guzmán, I., Gudayol-Ferré, E., Lira-Mandujano, J., Herrera-Abarca, J., Herrera-Guzmán, D., Montoya-Pérez, K., & Guardia-Olmos, J.
- Affiliations
- Secretaria de Salud (MX)
- Universidad Michoacana de San Nicolás de Hidalgo (MX)
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 160
- Issue
- 1
- Pages
- 72-82
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2145733800
- Cited by
- 78
- References
- 54
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 6 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consejo Nacional de Ciencia y Tecnología
- Universidad Michoacana de San Nicolás de Hidalgo
- Universitat de Barcelona
- FP7 International Cooperation
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- bupropion, major depressive disorder, antidepressant response, cognitive predictors, visual memory, processing speed
- MeSH terms
- Adult, Cognition Disorders, Delayed-Action Preparations, Major Depressive Disorder, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Male, Neuropsychological Tests, Brief Psychiatric Rating Scale, Predictive Value of Tests, Psychiatric Status Rating Scales, Severity of Illness Index, Bupropion, Treatment Outcome, Paroxetine, Antidepressive Agents, Second-Generation, Diagnostic and Statistical Manual of Mental Disorders
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