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Experimental and quasi-experimental designs in implementation research
Open accessAbstract
Implementation science is focused on maximizing the adoption, appropriate use, and sustainability of effective clinical practices in real world clinical settings. Many implementation science questions can be feasibly answered by fully experimental designs, typically in the form of randomized controlled trials (RCTs). Implementation-focused RCTs, however, usually differ from traditional efficacy- or effectiveness-oriented RCTs on key parameters. Other implementation science questions are more suited to quasi-experimental designs, which are intended to estimate the effect of an intervention in the absence of randomization. These designs include pre-post designs with a non-equivalent control group, interrupted time series (ITS), and stepped wedges, the last of which require all participants to receive the intervention, but in a staggered fashion. In this article we review the use of experimental designs in implementation science, including recent methodological advances for implementation studies. We also review the use of quasi-experimental designs in implementation science, and discuss the strengths and weaknesses of these approaches. This article is therefore meant to be a practical guide for researchers who are interested in selecting the most appropriate study design to answer relevant implementation science questions, and thereby increase the rate at which effective clinical practices are adopted, spread, and sustained.
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“Quasiexperiments are appropriate for practical situations and ethical compliance for studies involving vulnerable participants such as older adults, 17 and allow scholars to conduct rigorous studies under certain limitations and non-control conditions. 18”
From Mixed reality technology for older adults: Evaluating the impact of a novel virtual humanoid coach in a community-based physical exercise program in the Philippines (2024) · cites this paper as [18]
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“The determination of the sample size was based on the intact group technique, which is characteristic of quasi-experimental designs where randomization of individual subjects is not feasible due to institutional constraints (Leyrat et al., 2024; Miller et al., 2020).”
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“To control for the interaction between selection and maturation, the schools were randomly assigned to the control and treatment groups (Miller et al., 2020).”
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“According to Brown et al. (2017), experimental design is fundamental to scientific research, enabling researchers to establish cause-and-effect relationships through systematic manipulation of variables under controlled conditions.”
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McCluskey, S., Leif, E., Bloomfield, B. S., & Humm, P. (2025) · International Journal of Developmental Disabilities · doi:10.1080/20473869.2025.2557429 · Cited by 1
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Improving Problem Solving Skills using the Collaborative Problem Solving Model
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“The current study uses a pre-post, one-group quasi-experimental design to examine college students’ plausibility perspectives, allowing researchers to apply a treatment and assess participants’ views on a specific topic (Miller et al., 2020).”
Chuing, S. S., & Kutty, F. M. (2025) · International Journal of Academic Research in Progressive Education and Development · doi:10.6007/ijarped/v14-i1/24769 · Cited by 1
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Evaluation of hand-eye coordination fitness test performance in folk dance
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“…other hand, are the most reliable method to examine the effectiveness of new treatments or interventions (55), while the quasi-experimental design is more suitable for estimating the effect of an intervention when repeated measures design or analysis is used and pre-post testing is used (56, 57).”
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MethodUnlocking Communication Wonders: Exploring Transmitter and Receiver Concepts with p5.js
Septian, F. (2024) · Journal Software, Hardware and Information Technology · doi:10.24252/shift.v4i2.123 · Cited by 1
“The experimental design allows for a rigorous and systematic examination of research questions [4], contributing to the scientific rigor and validity of the study outcomes.”
MethodEffect of Ice Chips on Severity of Chemotherapy Induced Oral Mucositis
Mohamed, E. T., Hanafy, N. F., Farghaly, S. M., & Mahmoud, I. A. (2024) · Egyptian Journal of Health Care · doi:10.21608/ejhc.2024.379333 · Cited by 1
“The experimental group in this design receives the intervention and the effect can be assessed before and after the intervention (Miller, Smith, & Pugatch, 2020).”
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COOPERATIVE LEARNING FOR ENHANCED READING COMPREHENSION: A STUDY WITH FIRST-YEAR STUDENTS
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“This multi-step approach aimed to foster a more engaging and collaborative learning environment, promoting improved reading comprehension and learning outcomes among the students (Miller et al., 2020).”
BackgroundMethodSupriadi, D., Setiawan, E., Lobo, J., Budiman, A., Bulquerin, A. A., Parcon, L. M., Castro, J. J. D., Durana, K., Sison, K., Legarda, M., et al. (2023) · Fizjoterapia Polska · doi:10.56984/8zg20a657 · Cited by 1
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Opioid prescribing restrictions and opioid use among the Louisiana Medicaid population.
Callison, K., Karletsos, D., & Walker, B. (2022) · The International journal on drug policy · doi:10.1016/j.drugpo.2022.103770 · Cited by 1
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“The nonequivalent group (Fenland) was selected among the six areas of the county as the most suitable area to be compared with Peterborough based on similarities in the populations between the two areas and service provision, allowing assessment of whether the intervention impacted the area where it was implemented [3…”
MethodSari, E. F. N., Asmawi, M., Dlis, F., Susanti, D., & Siregar, N. M. (2021) · Journal of Physics, Conference Series · doi:10.1088/1742-6596/2019/1/012018 · Cited by 1
“The quasi-experimental research method was chosen because the class groups used were not random [12,13].”
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Noticing Formulaic Sequence through Typographic Enhancement Technique: Using an Online Platform
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“methods allow implementation scientists to perform rigorous studies in these settings, although with some limitations [30].”
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Ouazzani, E., Houria, Christiane, B., Angélique, P., & Lena, G. (2023) · Archives of Clinical and Medical Case Reports · doi:10.26502/acmcr.96550629 · Cited by 1
“Nevertheless, this design is interesting in implementation science when the randomization is not practicable for ethical and/or practical reasons because it allows identifying a change after the intervention from the analysis of repeated data collections [79, 80].”
BackgroundThe impact of New York City's Open Streets Program on local traffic
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Noviana, D., Fitriana, L., & Dharmansyah, D. (2026) · Journal Of Community Mental Health and Public Policy · doi:10.51602/cmhp.v9i1.450
“This study employed a quantitative approach with a quasi-experimental non-equivalent control group pretest-posttest design (Miller et al ., 2020).”
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Kriel, C., & Sakala, M. (2026) · Teaching & Learning Inquiry The ISSOTL Journal · doi:10.20343/teachlearninqu.14.47
“An interrupted time-series design involves repeated data collection at multiple points before and after an intervention to determine if an intervention associated with determining improvement on a given metric was successful or not (Miller, Smith, and Pugatch 2020).”
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Esan, B. T., Ngwai, Y. B., Akyala, A. I., Esan, O. A., Olugbemi, M. K., & Aremu, S. O. (2026) · Discover Public Health · doi:10.1186/s12982-026-02779-0
“In terms of study design, quantitative studies predominated, including randomized controlled trials (RCTs), quasi-experimental studies, and pre–post intervention designs [54–55].”
Paskali, J. (2026) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2026.v08i04.84293
“Miller et al. (2020) and Maciejewski (2020) have noted that the quasi-experimental design is commonly used to assess the effect of an intervention on two intact groups.”
Amponsah, J. K., Ellis, S. D., & Resnik, F. (2026) · Research Square · doi:10.21203/rs.3.rs-10616678/v1
“Randomized experiments are not the only appropriate approach to implementation research, but they remain important when the objective is to estimate the causal effect of an implementation strategy on implementation, service, or clinical outcomes (3–5).”
Poulsen, K., Hjorthøj, C. R., Bach, B., Simonsen, E. H., & Kongerslev, M. (2026) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-026-00346-2
“Future research should examine whether training that explicitly targets emotional labor and moral appraisal can influence long-term behavioral outcomes and whether structural interventions can modify institutional defenses over time [15, 25, 35, 36].”
InfluentialAplicaciones de la inteligencia artificial en la personalización del aprendizaje universitario
Puente, F. K. C., Olaya, M. D. L. P., Olaya, M. M. P., & Espín, B. M. L. (2026) · Boletín Científico Ideas y Voces · doi:10.60100/bciv.v6i3.320
Contreras, E. N. G., Godoy-Tapia, C., Rebolledo, P., & Molina-Márquez, I. (2026) · ESPACIOS · doi:10.48082/espacios-a26v47n04i07
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“This study adopted a post-intervention intact-class quasi-experimental design in a real university table tennis course to examine differences in students’ psychological need states and physical activity outcomes under platform-supported conditions (Miller et al., 2020).”
Sukarno, S., Wardana, A. B., Kusuma, I. K. A. A. W., & Nasikhudin (2026) · Ilomata International Journal of Tax and Accounting · doi:10.61194/ijtc.v7i3.2374
“This study employs a quasi-experimental research design using a simplified difference-in-differences (DiD) approach to examine changes in tax risk identification performance before and after the implementation of Artificial Intelligence-assisted financial statement analysis (Miller et al., 2020).”
The 3D4E strategic approach: Can GAI improve visual thinking skills in STEM high schools?
Abouelenein, Y. A. M., Selim, S. A. S., Azim, Z. M. A., & Khalaf, M. H. R. (2026) · Education and Information Technologies · doi:10.1007/s10639-026-14093-y
“- Supports positive emotions during practice for visual design experiments. tions in real classroom settings where full randomization is not feasible (Miller et al., 2020).”
Durotunnasihah, D., Sujarwati, I., & Kasmaini, K. (2026) · Journal Of Education And Teaching Learning (JETL) · doi:10.51178/jetl.v8i2.3359
“The study employed a quasi-experimental to observe the effect of the intervention across multiple time (Creswell, 2012; Miller et al., 2020) with repeated-measures within-subjects design.”
Firmansyah, A., Herlina, H., Muchdar, M., Muslim, M., & Mas'adi, M. (2026) · SCAFFOLDING: Jurnal Pendidikan Islam dan Multikulturalisme · doi:10.37680/scaffolding.v8i2.9974
“This design was chosen because it is suitable for research in a school environment that does not allow strict subject randomization, but can still control external variables by administering pre-and post-tests (Miller et al., 2020).”
Althobaiti, S., Said, F., & Alawag, A. M. (2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.61s.72
Osa, S. T.-L., Lobato-Rayo, F., Martín-Ruiz, E., & Lima, A. O. D. L. (2026) · Journal of Medical Entomology · doi:10.1093/jme/tjag095
Dalimunthe, S. A., Yurniwati, & Nurjannah (2026) · SOSIOEDUKASI : JURNAL ILMIAH ILMU PENDIDIKAN DAN SOSIAL · doi:10.36526/sosioedukasi.v15i2.8296
“Reliability refers to the extent to which measurements or experimental procedures produce consistent interpretations of the construct to be measured (Miller et al., 2020).”
Raúl, P. E. L., Mauricio, P. L. D., Lucrecia, C. C. E., & Jesús, M. C. E. (2026) · Revista Iberoamericana de Educación · doi:10.31876/rie.v10i3.375
“Según Miller et al. (2020), este diseño constituye una alternativa intermedia entre los ensayos controlados aleatorios y los estudios observacionales, mientras que (Campbell et al., 1963) destacan que los cuasi - experimentos, aunque con menor control que los experimentos puros, resultan más…”
Martins, A., Santos, M. F. B., Nascimento, J., Chui, F. M. D. S., Rodrigues, M. G. A., Bastos, T., Lemos, S., Honorato, E., Cortez, M., Xavier, M., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0351566
“This approach enabled meaningful comparisons across key outcomes despite the lack of randomization and practical, ethical, social, and logistical restrictions [24,25].”
Pertiwi, M., & Gidena, A. (2026) · Schrödinger: Journal of Physics Education · doi:10.37251/sjpe.v7i3.3394
Hasan, I. F. (2026) · Journal of Research in Interactive Marketing · doi:10.1108/jrim-01-2026-0054
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Shindhe, S., & Chouhan, D. (2026) · Genetics and Molecular Research · doi:10.4238/jm75m598
“When comparing an intervention group to a control group is necessary but random assignment is not practical, this design is frequently employed in health and implementation research (Miller et al., 2020).”
Huang, Y., Taylor, D., Kubler, M., Burger, S.-A., Itallie, A. K. V., Vandelanotte, C., & Robinson, M. (2026) · Journal of Physical Activity and Health · doi:10.1123/jpah.2025-0740
Romli, R., Nawi, A. M., Rahman, R. A., Mohamad, E. M. W., Chew, K. T., & Hashim, S. M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0347489
“However, there are challenges in implementing quasi-experimental study regarding the threats of internal validity that can arise from non-randomization sampling [27].”
Atitsogbey, P., Kyereh, E., Wang, D.-T., Annor, G., & Steiner-Asiedu, M. (2026) · BMC Nutrition · doi:10.1186/s40795-026-01353-w
“This study employed a quasi-experimental pretest– posttest control group design [36] and was conducted in the Ayawaso Central Municipal Assembly, Greater Accra, Ghana.”
Musa, N., Lee, H.-Y., Nor, N. B. M., Sunarti, S., Syahrul, N., & Fadlly, H. (2026) · PaperASIA · doi:10.59953/paperasia.v42i2b.1069
“Although matching helped reduce baseline bias, future research could strengthen validity by implementing random assignments across multiple schools to enhance the robustness of hybrid learning impact evaluation (Chen et al., 2020; Miller et al., 2020).”
InfluentialYueh, F.-R., Lin, C.-Y., Fang, T.-J., Hsieh, P.-L., Wang, J.-L., & Hu, F.-W. (2026) · Journal of Hospital Infection · doi:10.1016/j.jhin.2026.05.001
Diño, M. J. S., Thiamwong, L., Xie, R., Enriquez, A. J., Malacas, M. K. G., Hernandez, R., Vital, J. C., Banarjee, C., Daher, S., Abadir, P. M., et al. (2026) · Computers in Human Behavior Reports · doi:10.1016/j.chbr.2026.101115
Sekarani, T. S., Akhsan, H., & Kistiono, K. (2026) · Indonesian Journal of Education Research (IJoER) · doi:10.37251/ijoer.v7i2.2369
“It provides a practical and validated solution to the dual challenge of implementing the Merdeka Curriculum while fostering 21st-century skills [42] – [44].”
Nguyen, P. T. T., Duong, D., Tran, A. V., Nguyen, L., Anh, L. D., Hoàng, D. V., & Trần, N. K. (2026) · Hospital Pharmacy · doi:10.1177/00185787261433442
Wang, R., & Li, Z. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1775237
“The development of quasi-experimental designs (16) and implementation research methods (17) provides methodological foundations for evaluating such integration models.”
Sanders, M. R., Burke, K., Haynes, M. A., Baxter, J., Western, M., Chainey, C., & Prinz, R. J. (2026) · Journal of Child and Family Studies · doi:10.1007/s10826-026-03298-x
Leliya, & Mujahidin, M. (2026) · Dimasejati: Jurnal Pengabdian Kepada Masyarakat · doi:10.70095/dimasejati.v8i1.23834
“…tiga pilar utama (Bunselmeyer & Schulz, 2020; Dawson et al., 2021; Galdo-Castiñeiras, Hernández-Morante, Morales-Moreno, & Echevarría-Pérez, 2023; Miller, Smith, & Pugatch, 2020): (1) peningkatan literasi hukum individual, (2) penguatan kapasitas kolektif komunitas, dan (3) institusionalisasi…”
Lastimado, A. E., Macapili, A. C., Pantaleon, A. G., Ebarle, R. L. P., Simugan, J. S., Añora, F. D., Capunong, N. A., & Salazar, W. (2026) · International Journal of Mechanical Engineering Education · doi:10.1177/03064190261435859
Zaky, M., Abdallah, H. M. M., Elsayed, S., & Farghaly, S. (2026) · Advances in Skin & Wound Care · doi:10.1097/asw.0000000000000429
Transient motivation? A mixed-methods study of gamification in agile requirements change management
Rusdianto, D. S., Yuhana, U. L., Fabroyir, H., & Riefard, R. M. (2026) · Acta Psychologica · doi:10.1016/j.actpsy.2026.106639
Leveraging DeepL Write to Improve Writing Performance among Vocational High School Students
Hardita, C. D., Triprihatmini, V., & Handayani, S. (2026) · Research and Innovation in Applied Linguistics · doi:10.31963/rial.v4i1.5818
“Experimental was a method that involved the use of an independent variable as the treatment group and a dependent variable as the control group to assess the effects of a particular variable (Miller et al., 2020).”
A Review: Research Trends on Local Wisdom-Based Empathy Values in Science Learning
Iksan, M., Isa, I., Ahmad, J., Latjomph, M., Yusuf, F. M., & Kaili, A. S. (2026) · Jurnal Penelitian Pendidikan IPA · doi:10.29303/jppipa.v12i2.14255
“Methodologically, the dominance of qualitative and short-term studies indicates the need for more rigorous experimental and longitudinal designs to strengthen causal claims (Miller et al., 2020; Grosz et al., 2020).”
Al-Homayin, M. A., & Alzahrani, M. A. (2026) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2026.2627991
“An experimental pre-post intervention design (Harris et al, 2005; Miller, Smith, and Pugatch, 2019) assessed the impact of OGT vs TGT on post-stroke QoL and walking performance.”
Arianto, A., Mulyati, Y., Yulianeta, Y., & Cahyani, I. (2026) · Journal of Innovation in Educational and Cultural Research · doi:10.46843/jiecr.v7i2.2644
“In this design, the researcher measures the dependent variable before and after the treatment (intervention) to assess changes (Creswell, 2015; Fraenkel et al., 1993; Miller et al., 2020).”
Philosophy programs in prison and rehabilitative outcomes – A scoping review
Góis, I., Kane, E., Evans, E., & Doney, E. (2026) · Philosophical Psychology · doi:10.1080/09515089.2026.2627312
Hidayat, A., Setyawati, H., Hidayatullah, F., Hasanah, N., Purnomo, E., & Supriyanto, S. (2026) · Retos · doi:10.47197/retos.v77.118644
“Yet, it still provides adequate internal validity (Miller et al., 2020).”
The Impact of Contextual Teaching and Learning on Students’ Communication Skills
Asyari, A., & Rasidi, M. A. (2026) · International Journal of Teaching · doi:10.61798/ijt.v3i1.429
“This study used a quasi-experimental pretest – posttest control group design (Miller et al., 2020) to examine the effect of the Contextual Teaching and Learning (CTL) model on students’ communication skills.”
Evaluating midwife-led continuity of care and breastfeeding outcomes: A quasi-experimental study.
Shipton, E. V., Lee, N., Foxcroft, K., de Jersey, S. D., & Callaway, L. (2026) · Women and Birth · doi:10.1016/j.wombi.2026.102167
POLICY EVALUATION AND THE ROLE OF NARCOTICS REHABILITATION INSTITUTION S IN NORTH SULAWESI
Punuhsingon, J., Simamora, P. N. S., Paendong, K., Kampilong, J. K., Andes, A. M., Sumilat, R., Gumansing, C., & Palilingan, J. (2026) · SOSIOEDUKASI : JURNAL ILMIAH ILMU PENDIDIKAN DAN SOSIAL · doi:10.36526/sosioedukasi.v14i4.6748
“Second, it uses a longitudinal quasi-experimental design with 400 people and repeated monthly measurements over a period of 12 months, and secondary and primary data through an ETL pipeline (Miller et al., 2020).”
Measuring the Preservice Counselor’s belief-diagnostic competence
Hanafi, H., Ramli, M., Hambali, I., Apriani, R., & Kurniawan, N. A. (2025) · JKI (Jurnal Konseling Indonesia) · doi:10.21067/jki.v11i1.14026
“This study used quantitative non experiment with a descriptive evaluation design (Creswell & Creswell, 2023; Miller et al., 2020).”
Berhe, K. K., Mselle, L. T., & Gebru, H. B. (2025) · ASRIC Journal on Health Sciences · doi:10.68327/hmgs5363
Kurniawan, I., & Marfu'ah, I. (2025) · Riemann: Research of Mathematics and Mathematics Education · doi:10.38114/riemann.v7i3.119
“Therefore, researchers must control internal validity threats using other design and analysis techniques (e.g., nonequivalent control groups, regression, difference-in-differences) (Ballance, 2024; Miller et al., 2020).”
Factors Promoting Retention of HIV/AIDS Clients with Suspected Treatment Failure at Kakamega County
Sum, T., Mengich, G., Kenny, D., Mutai, C., Ekisa, M., Jerop, M., Dewing, G., Odoyo, C., Wesonga, B. O., Thuo, J., et al. (2025) · Pan-African Journal of Health and Environmental Science · doi:10.56893/ajhes2025v04i02.12
Experiment as a research method for investigating the effectiveness of drama in EFL Higher Education
Kolar, M., & Sándorová, Z. (2025) · Glottodidactica · doi:10.14746/gl.2025.52.2.7
Agus, Ari, M. D., & Arahmin, R. (2025) · Jurnal PROGRESS Wahana Kreativitas dan Intelektualitas · doi:10.31942/pgrs.v13i2.14348
“In this design, participants are divided into two groups: an experimental group and a control group (Miller, Smith, & Pugatch, 2020).”
Przywarra), T. B. (., & Risch, B. (2025) · Journal of Chemical Education · doi:10.1021/acs.jchemed.5c00231
Metadata
- Authors
- Miller, C. J., Smith, S. N., & Pugatch, M.
- Affiliations
- United States Department of Veterans Affairs (US)
- University of Michigan (US)
- Corresponding author
- Miller, Christopher J.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 283
- Pages
- 112452
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC6923620
- OpenAlex
- W2951715721
- Cited by
- 373
- References
- 67
- Citations by year
- 2026: 63 · 2025: 89 · 2024: 67 · 2023: 63 · 2022: 56 · 2021: 20 · 2020: 14
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychiatry Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health
- U.S. Department of Veterans Affairs
- Topics
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Keywords
- implementation research, implementation science, experimental design, quasi-experimental design, randomized controlled trials, interrupted time series, stepped wedge design, pre-post design, research design selection, clinical adoption, intervention sustainability
- MeSH terms
- Implementation Science, Humans, Research Design, Randomized Controlled Trials as Topic, Control Groups, Biomedical Research
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