Clinical validation of combinatorial pharmacogenomic testing and single-gene guidelines in predicting psychotropic medication blood levels and clinical outcomes in patients with depression

Rothschild, Anthony J.; Parikh, Sagar V.; Hain, Daniel; Law, Rebecca; Thase, Michael E.; Dunlop, Boadie W.; DeBattista, Charles; Conway, Charles R.; Forester, Brent P.; Shelton, Richard C.; Macaluso, Matthew; Brown, Krystal; Lewis, David; Gutin, Alexander; Jablonski, Michael R.; Greden, John F.

doi:10.1016/j.psychres.2020.113649

Clinical validation of combinatorial pharmacogenomic testing and single-gene guidelines in predicting psychotropic medication blood levels and clinical outcomes in patients with depression

We evaluated the clinical validity of a combinatorial pharmacogenomic test and single-gene Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines against patient outcomes and medication blood levels to assess their ability to inform prescribing in major depressive disorder (MDD). T…