The effect of berberine adjunctive treatment on glycolipid metabolism in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial
Abstract
Previous studies have shown that berberine can improve metabolic disturbances in non-psychiatric patients, but no clinical research has been conducted in schizophrenia. This study was a randomized, double-blind, placebo-controlled clinical trial. Eligible patients diagnosed with schizophrenia were randomized to receive placebo or berberine (900mg/day) as an adjunctive treatment for eight weeks. Peripheral glycolipid metabolism parameters were measured at baseline, week 4, and week 8. Sixty-five patients were included, and forty-nine patients completed the 8-week trial. Berberine led to significant declines in total cholesterol, low-density lipoprotein cholesterol, fasting serum insulin, and insulin resistance(all p<0.05) compared with placebo. Baseline body mass index and serum prolactin concentration could predict the effect of berberine on insulin resistance. Berberine adjunctive treatment may reduce the risk of glycolipid metabolic disturbances in patients with schizophrenia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Two publications from the same authors were considered the same study, and only data from the earlier publication were presented to avoid duplication.
“We identified two publications from the same authors that we considered to be the same study, with one study published in Chinese and the other in English.(29, 30) To avoid duplication, we only present data from the earlier publication as the sample size was larger and the study report was more detailed.”
From Overall and sex-specific effect of berberine for dyslipidemia: systematic review and meta-analysis of placebo-controlled trials (2022) · cites this paper as [30]
The citation lists haven’t been fetched yet
References 42 · Cited by 21
- Authors
- Li, M., Liu, Y., Qiu, Y., Zhang, J., Zhang, Y., Zhao, Y., Jia, Q., & Li, J.
- Affiliations
- Tianjin Anding Hospital (CN)
- Soochow University (CN)
- Corresponding author
- Li, Jie
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 300
- Pages
- 113899
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W3137719537
- Cited by
- 21
- References
- 42
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 8 · 2022: 3 · 2021: 2
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- berberine, schizophrenia, glycolipid metabolism, insulin resistance, hypertriglyceridemia, hypercholesterolemia, adjunctive therapy, body mass index, prolactin, metabolic disorders
- MeSH terms
- Berberine, Double-Blind Method, Glycolipids, Humans, Schizophrenia, Antipsychotic Agents, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
