The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Clinical burnout is not reflected in the cortisol awakening response, the day curve or the response to a low-dose dexamethasone suppression test
Abstract
Burnout is presumed to be the result of chronic stress, and chronic stress is known to affect the HPA-axis. To date, studies on HPA-axis functioning in burnout have showed inconsistent results. In the present study, a large sample (n=74) of clinically diagnosed burnout individuals, mostly on sick-leave, were included and compared with 35 healthy controls. Salivary cortisol was sampled on 2 days to determine the cortisol awakening response (CAR) and the day-curve. In addition, the dexamethasone suppression test (DST) was applied to assess the feedback efficacy of the HPA-axis. There were no differences observed in the CAR, day-curve or CAR after DST in the burnout group as compared to a healthy control group. Burnout shows overlap in symptoms with chronic fatigue syndrome (CFS) and depression. Therefore, differential changes in HPA-axis functioning that resemble the hypo-functioning of the HPA-axis in CFS, or rather the hyper-functioning of the HPA-axis in depression, might have obscured the findings. However, no effect of fatigue or depressive mood on HPA-axis functioning was found in the burnout group. We concluded that HPA-axis functioning in clinically diagnosed burnout participants as tested in the present study, seems to be normal.
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“but positively correlated in another (Mommersteeg et al., 2006)”
From Psychosocial functioning and the cortisol awakening response: meta-analysis, P-curve analysis, and evaluation of the evidential value in existing studies (2017) · cites this paper as Mommersteeg et al., 2006
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Prevalencia del Síndrome de Burnout en personal sanitario militar
Bermejo, G. G. C. (2011) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
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van den Bunt, M., Arns, M., Verbraak, M. J. P. M., Keijsers, G. P. J., & van Luijtelaar, G. (2010) · Neuropraxis · doi:10.1007/s12474-010-0814-3
Self-citationLee, H.-S., Jun, C.-Y., & Choi, Y.-K. (2016) · The Journal of Internal Korean Medicine · doi:10.22246/jikm.2016.37.6.1059
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De l’importance des médiateurs du stress dans le contrôle de l’immunité
Bacou, E. (2017) · theses.fr (ABES) · doi:10.70675/c3e20630z2e84z4f0ez9c4ez2ff5647f0f03
Metadata
- Authors
- Mommersteeg, P. M. C., Heijnen, C. J., Verbraak, M. J. P. M., & van Doornen, L. J. P.
- Affiliations
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- HSK Groep (NL)
- Corresponding author
- Mommersteeg, Paula M.C.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 31
- Issue
- 2
- Pages
- 216-225
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2097041359
- Cited by
- 111
- References
- 52
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 8
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Stress and Burnout Research
- Health Sciences › Health Professions › General Health Professions › Healthcare professionals’ stress and burnout
- Keywords
- burnout, cortisol awakening response, hypothalamic-pituitary-adrenal axis, dexamethasone suppression test, chronic stress, salivary cortisol, chronic fatigue syndrome, depression, fatigue, sick leave
- MeSH terms
- Adult, Analysis of Variance, Burnout, Professional, Circadian Rhythm, Dexamethasone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Reference Values, Saliva, Wakefulness, Chi-Square Distribution, Statistics, Nonparametric, Area Under Curve, Feedback, Physiological
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