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Cited by 152Stress Responses and CortisolAdrenal Hormones and DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The cortisol awakening response is blunted in psychotherapy inpatients suffering from depression

Huber, Thomas J., Issa, Katharina, Schik, Gesa, Wolf, Oliver T.·2006·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2006.03.005
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Abstract

Determining the salivary awakening cortisol response (ACR) is a non-invasive, reliable method to detect changes in the hypothalamus-hypopituitary-adrenal (HPA) axis. Although a role of the HPA axis in depression is widely recognized, data on the ACR in depressive patients are still scarce and inconsistent. The present study assessed the ACR in depressed patients admitted for inpatient psychotherapy and a comparison group of other psychiatric diagnoses under the same conditions. The ACR was found to be attenuated in depressed as compared to non-depressed patients. This finding is in contrast to previous studies in healthy subjects or depressed outpatients and suggests a blunted rather than an exacerbated HPA reactivity. Further studies will be needed to disentangle the complex relationship between depression and the ACR.

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  • Cross-sectional associations between the CAR and depression are mixed: some studies find lower CARs in current MDD, others find current MDD or high depressive symptoms associated with higher CARs.

    “Studies examining cross-sectional associations between the CAR and depression have found mixed results: some have found significantly lower CARs in individuals with current MDD diagnoses (Huber et al., 2006; Stetler and Miller, 2005), whereas others have found current MDD or high depressive symptoms to be associated with higher CARs (Bhagwagar et al., 2005; Pruessner et al., 2003).”

    From Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence (2010) · cites this paper as Huber et al., 2006

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References 20 · Cited by 152

Authors
Huber, T. J., Issa, K., Schik, G., & Wolf, O. T.
Affiliations
  • Medizinische Hochschule Hannover (DE)
  • Bielefeld University (DE)
Corresponding author
Huber, Thomas J.
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2006-08
Volume
31
Issue
7
Pages
900-904
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2006.03.005
OpenAlex
W2101712015
Cited by
152
References
20
Citations by year
2025: 2 · 2024: 2 · 2023: 9 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 15 · 2012: 10
FWCI
2.87
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
cortisol awakening response, depression, hypothalamic-pituitary-adrenal axis, salivary cortisol, inpatient psychotherapy, psychiatric inpatients
MeSH terms
Adult, Circadian Rhythm, Depressive Disorder, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Inpatients, Male, Middle Aged, Pituitary-Adrenal System, Psychotherapy, Saliva, Wakefulness, Statistics, Nonparametric

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