Effects of social isolation on mRNA expression for corticotrophin-releasing hormone receptors in prairie voles
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Previous studies have demonstrated that various type of stressors modulate messenger ribonucleic acid (mRNA) for type 1 corticotropin-releasing hormone (CRH) receptor (CRH-R1 mRNA) and type 2 CRH receptor (CRH-R2 mRNA). The purpose of this study was to explore the effect of social isolation stress of varying durations on the CRH, CRH-R1 and CRH-R2 mRNAs expression in the hypothalamus, hippocampus and pituitary of socially monogamous female and male prairie voles (Microtus ochrogaster). Isolation for 1h (single isolation) or 1h of isolation every day for 4 weeks (repeated isolation) was followed by a significant increase in plasma corticosterone levels. Single or repeated isolation increased hypothalamic CRH mRNA expression, but no changes in CRH-R1 mRNA in the hypothalamus were observed. Continuous isolation for 4 weeks (chronic isolation) showed no effect on hypothalamic CRH or CRH-R1 mRNAs in female or male animals. However, hypothalamic CRH-R2 mRNA was significantly reduced in voles exposed to chronic isolation. Single or repeated isolation, but not chronic isolation, significantly increased CRH-R1 mRNA and decreased CRH-R2 mRNA in the pituitary. Despite elevated CRH mRNA expression, CRH-R1 and CRH-R2 mRNAs were not modulated in the hippocampus following single or repeated isolation. Although, chronic isolation did not affect hippocampal CRH or CRH-R1 mRNAs, it did increase CRH-R2 mRNA expression in females and males. The results of the present study in prairie voles suggest that social isolation has receptor subtype and species-specific consequences for the modulation of gene expression for CRH and its receptors in brain and pituitary. Previous studies have revealed a female-biased increase in oxytocin in response to chronic isolation; however, we did not find a sex difference in CRH or its receptors following single, repeated or chronic social isolation, suggesting that sexually dimorphic processes beyond the CRH system, possibly involving vasopressin, might explain this difference.
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A shorter 1-hour isolation in adult prairie voles housed with same-sex siblings increased hypothalamic and hippocampal CRF mRNA.
“a shorter period (1 h) of social isolation in adult male and female prairie voles housed with same-sex siblings, resulted in increased hypothalamic and hippocampal CRF mRNA83.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [83]
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References 52 · Cited by 53
- Authors
- Pournajafi-Nazarloo, H., Partoo, L., Yee, J., Stevenson, J., Sanzenbacher, L., Kenkel, W., Mohsenpour, S. R., Hashimoto, K., & Carter, C. S.
- Affiliations
- University of Illinois Chicago (US)
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 36
- Issue
- 6
- Pages
- 780-789
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC3104077
- OpenAlex
- W2077995837
- Cited by
- 53
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Child Health and Human Development
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- social isolation, corticotropin-releasing factor, CRH receptor 1, CRH receptor 2, Microtus ochrogaster, hypothalamus, hippocampus, pituitary gland, corticosterone, chronic stress, sex differences, oxytocin, vasopressin, gene expression
- MeSH terms
- CRF Receptor, Type 1, Animals, Corticosterone, Arvicolinae, Female, Hippocampus, Hypothalamo-Hypophyseal System, Hypothalamus, Male, Oxytocin, Pituitary Gland, Pituitary-Adrenal System, Random Allocation, RNA, Messenger, Sex Characteristics, Social Isolation, Species Specificity, Stress, Psychological, Transcription, Genetic, Vasopressins, Receptors, Corticotropin-Releasing Hormone
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