Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV
Open accessAbstract
Background Sleep disturbance is associated with dopamine dysregulation, which can negatively impact immune status. Individuals living with HIV experience more sleep difficulties, and poor sleep may compound immune decrements associated with HIV infection. Little research has examined associations between sleep, dopamine, and immune status (CD4 count) in individuals with HIV. As ethnic minority women living with HIV (WLWH) are at heightened risk for HIV disease progression, we related sleep reports to both CD4 count and dopamine levels in a cohort of ethnic minority WLWH.Methods Participants were 139 low-income WLWH (ages 20-62; 78.3% African-American or Caribbean) who reported both overall sleep quality and sleep disturbance on the Pittsburgh sleep quality index (PSQI). CD4 count and HIV viral load were measured via morning peripheral venous blood samples, and concentrations of dopamine were measured via 24-h urine collection. Covariates included HIV viral load, length of time since HIV diagnosis, HAART adherence, perceived stress and depression.Results After controlling for all covariates, greater sleep disturbance was associated with significantly lower CD4 count (β=-.20, p=.03) and lower levels of dopamine (β=-.25, p=.04). Poorer overall sleep quality was marginally associated with lower CD4 count (β=-.16, p=.08), and was not associated with dopamine.Conclusion Our analyses suggest that sleep disturbance is independently related with immune status and dopamine levels in WLWH. Lower levels of dopamine may indicate neuroendocrine dysregulation and may impact immune and health status. Results highlight sleep disturbance rather than overall sleep quality as potentially salient to neuroendocrine and immune status in ethnic minority WLWH.
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Autoreactive T and B cells can regulate inflammatory processes in the brain.
“Autoreactive T and B cells add an additional level of complexity, as they can regulate inflammatory processes in the brain (291, 499) and might represent a reflection of ‟our self,ˮ the ‟immunculus,ˮ to restore homeostasis of tissues and organs (441).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [499]
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References 51 · Cited by 70
- Authors
- Seay, J. S., McIntosh, R., Fekete, E. M., Fletcher, M. A., Kumar, M., Schneiderman, N., & Antoni, M. H.
- Affiliations
- University of Miami (US)
- University of Indianapolis (US)
- Corresponding author
- Seay, Julia S.
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 38
- Issue
- 11
- Pages
- 2647-2653
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC3812316
- OpenAlex
- W2112425864
- Cited by
- 70
- References
- 51
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 8 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 2
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- Funders
- University of Miami Biopsychosocial Research Training in Immunology and AIDS Grant (5T32MH018917-24)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep disorders, HIV, CD4 count, dopamine, urinary dopamine, immune status, ethnic minority women, African American women, Caribbean women, sleep quality, neuroendocrine dysfunction, HIV viral load, HAART adherence, depression, perceived stress
- MeSH terms
- Adult, Black or African American, Dopamine, Ethnicity, Female, Humans, Sleep Initiation and Maintenance Disorders, Middle Aged, Poverty, HIV Infections, Caribbean Region, CD4 Lymphocyte Count, Viral Load, Self Report
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