Serum brain-derived neurotrophic factor, Val66Met polymorphism and open-label SSRI treatment response in Major Depressive Disorder

Smit, Anna J.T.; Wu, Gwyneth W.Y.; Rampersaud, Ryan; Reus, Victor I.; Wolkowitz, Owen M.; Mellon, Synthia H.

doi:10.1016/j.psyneuen.2024.107045

Serum brain-derived neurotrophic factor, Val66Met polymorphism and open-label SSRI treatment response in Major Depressive Disorder

BACKGROUND Brain-derived neurotrophic factor (BDNF) has been implicated in the therapeutic action of antidepressants and possibly in the pathophysiology of Major Depressive Disorder (MDD). Clinical studies of peripheral blood levels of BDNF in MDD have provided conflicting results, and there are …