Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?
Abstract
Disruption of the endothelial cell (EC) barrier leads to pathology via edema and inflammation. During infections, pathogens are known to invade the EC barrier and modulate vascular permeability. However, ECs are semi-professional antigen-presenting cells, triggering T-cell costimulation and specific immune-cell activation. This in turn leads to the release of inflammatory mediators and the destruction of infected cells by effectors such as CD8(+) T-cells. During malaria, transfer of parasite antigens to the EC surface is now established. At the same time, CD8 activation seems to play a major role in cerebral malaria. We summarize here some of the pathways leading to antigen presentation by ECs and address the involvement of these mechanisms in the pathophysiology of cerebral malaria.
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Upon viral infection, endothelial MHC-I presents endogenous viral products and facilitates CD8+ T cell activation.
“Upon viral infection, endothelial MHC-I presents endogenous viral products and facilitates CD8+ T cell activation (44–46).”
From Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease (2020) · cites this paper as [45]
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References 100 · Cited by 33
- Authors
- Razakandrainibe, R., Pelleau, S., Grau, G. E., & Jambou, R.
- Affiliations
- Institut Pasteur de Madagascar (MG)
- The University of Sydney (AU)
- Venue
- Trends in Parasitology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 28
- Issue
- 4
- Pages
- 151-160
- ISSN
- 1471-4922 (ISSN-L)
- OpenAlex
- W2060397744
- Cited by
- 33
- References
- 100
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 4 · 2015: 3 · 2013: 3 · 2012: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- endothelial cells, antigen presentation, malaria, cerebral malaria, endothelial barrier disruption, vascular permeability, CD8+ T cells, T cell costimulation, parasite antigens, inflammation, malaria pathophysiology
- MeSH terms
- Animals, Antigens, Protozoan, Cell Membrane Permeability, Humans, Malaria, Plasmodium, Antigen Presentation, Endothelial Cells
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