Animal African trypanosomiasis: time to increase focus on clinically relevant parasite and host species
Open accessAbstract
Animal African trypanosomiasis (AAT), caused by Trypanosoma congolense and Trypanosoma vivax, remains one of the most important livestock diseases in sub-Saharan Africa, particularly affecting cattle. Despite this, our detailed knowledge largely stems from the human pathogen Trypanosoma brucei and mouse experimental models. In the postgenomic era, the genotypic and phenotypic differences between the AAT-relevant species of parasite or host and their model organism counterparts are increasingly apparent. Here, we outline the timeliness and advantages of increasing the research focus on both the clinically relevant parasite and host species, given that improved tools and resources for both have been developed in recent years. We propose that this shift of emphasis will improve our ability to efficiently develop tools to combat AAT.
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There is a difference in trypanosome-specific antiparasite antibody secreting cells in spleen and B cell activation between trypanotolerant and trypanosusceptible cattle.
“There is a difference in trypanosome-specific antiparasite Ab secreting cells in spleen and B cell activation between trypanotolerant and trypanosusceptible cattle (La Greca et al., 2014; Mamoudou et al., 2016; Morrison et al., 2016).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Morrison et al., 2016
The available indexed passages are a publication listing (no page given) and project information, not discussion of cattle immune responses. Searches for trypanotolerance, splenic antibody-secreting cells, and B-cell activation found no passage addressing the claimed difference. (LLM, conf=0.72)
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References 56 · Cited by 146
- Authors
- Morrison, L. J., Vezza, L., Rowan, T., & Hope, J. C.
- Affiliations
- Roslin Institute (GB)
- Global Alliance for Livestock Veterinary Medicines (GB)
- Corresponding author
- Morrison, Liam J.
- Venue
- Trends in Parasitology
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 32
- Issue
- 8
- Pages
- 599-607
- ISSN
- 1471-4922 (ISSN-L)
- OpenAlex
- W2346143562
- Cited by
- 146
- References
- 56
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 11 · 2023: 11 · 2022: 28 · 2021: 15 · 2020: 21 · 2019: 21 · 2018: 11 · 2017: 15 · 2016: 1
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Trends in Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Bill and Melinda Gates Foundation (BB/J004227/1)
- Government of the United Kingdom
- Biotechnology and Biological Sciences Research Council (BB/N007492/1, 1509513, BB/M012808/1, BB/J004227/1, BB/L019035, BB/L019035/1)
- Topics
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- African animal trypanosomosis, tsetse flies, Trypanosoma congolense, Trypanosoma vivax, cattle, host species, parasite species, Trypanosoma brucei, comparative genomics, host-parasite interactions, livestock diseases, sub-Saharan Africa
- MeSH terms
- Animals, Host-Parasite Interactions, Research, Trypanosoma, Trypanosomiasis, African, Africa South of the Sahara
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