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Cited by 38Parasites and Host InteractionsProtease and Inhibitor MechanismsHelminth infection and control

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Protease Inhibitors of Parasitic Flukes: Emerging Roles in Parasite Survival and Immune Defence

Ranasinghe, Shiwanthi L., McManus, Donald P.·2017·Trends in Parasitology
DOI 10.1016/j.pt.2016.12.013
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Abstract

Protease inhibitors play crucial roles in parasite development and survival, counteracting the potentially damaging immune responses of their vertebrate hosts. However, limited information is currently available on protease inhibitors from schistosomes and food-borne trematodes. Future characterization of these molecules is important not only to expand knowledge on parasitic fluke biology but also to determine whether they represent novel vaccine and/or drug targets. Moreover, protease inhibitors from flukes may represent lead compounds for the development of a new range of therapeutic agents against inflammatory disorders and cancer. This review discusses already identified protease inhibitors of fluke origin, emphasizing their biological function and their possible future development as new intervention targets.

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Metadata

Authors
Ranasinghe, S. L., & McManus, D. P.
Affiliations
QIMR Berghofer Medical Research Institute (AU)
Corresponding author
  • Ranasinghe, Shiwanthi L.
  • McManus, Donald P.
ORCID
Venue
Trends in Parasitology
Publisher
Elsevier BV
Published
2017-05
Volume
33
Issue
5
Pages
400-413
ISSN
1471-4922 (ISSN-L)
DOI
10.1016/j.pt.2016.12.013
OpenAlex
W2578266761
Cited by
38
References
2
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 1
FWCI
0.57
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Parasitology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • QIMR Berghofer Medical Research Institute
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
Keywords
protease inhibitors, schistosomes, trematodes, host immune defense, parasite survival, vaccine targets, therapeutic target, host-parasite interactions, inflammatory diseases, cancer therapy
MeSH terms
Animals, Host-Parasite Interactions, Humans, Inflammation, Neoplasms, Protease Inhibitors, Trematoda, Trematode Infections, Drug Discovery

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