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Cited by 308Advanced Radiotherapy TechniquesMedical Image Segmentation TechniquesRadiation Dose and Imaging

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

A cardiac contouring atlas for radiotherapy

Open access
Duane, Frances, Aznar, Marianne C., Bartlett, Freddie, Cutter, David J., Darby, Sarah C., Jagsi, Reshma, Lorenzen, Ebbe L., McArdle, Orla, McGale, Paul, Myerson, Saul, Rahimi, Kazem, Vivekanandan, Sindu, Warren, Samantha, Taylor, Carolyn W.·2017·Radiotherapy and Oncology
DOI 10.1016/j.radonc.2017.01.008PMC PMC5356506
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Abstract

Background and purpose The heart is a complex anatomical organ and contouring the cardiac substructures is challenging. This study presents a reproducible method for contouring left ventricular and coronary arterial segments on radiotherapy CT-planning scans. Material and methods Segments were defined from cardiology models and agreed by two cardiologists. Reference atlas contours were delineated and written guidelines prepared. Six radiation oncologists tested the atlas. Spatial variation was assessed using the DICE similarity coefficient (DSC) and the directed Hausdorff average distance ( d → H , avg ). The effect of spatial variation on doses was assessed using six different breast cancer regimens. Results The atlas enabled contouring of 15 cardiac segments. Inter-observer contour overlap (mean DSC) was 0.60–0.73 for five left ventricular segments and 0.10–0.53 for ten coronary arterial segments. Inter-observer contour separation (mean d → H , avg ) was 1.5–2.2mm for left ventricular segments and 1.3–5.1mm for coronary artery segments. This spatial variation resulted in <1Gy dose variation for most regimens and segments, but 1.2–21.8Gy variation for segments close to a field edge. Conclusions This cardiac atlas enables reproducible contouring of segments of the left ventricle and main coronary arteries to facilitate future studies relating cardiac radiation doses to clinical outcomes.

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Crossref · 10.1016/j.radonc.2017.01.008

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Figures

Fig. 1 Identifying the atrioventricular and inter-ventricular grooves. (a and b) Anterior (a) and posterior (b) view of the whole heart illustrating the cardiac axis, the cardiac chambers, and the atrioventricular and inter-ventricular grooves. The cardiac axis projects through the centre of the base of the heart (the left atrium) towards the cardiac apex. The acute heart border is the horizontal heart border extending from the lower right edge of the heart to the apex, which is formed mainly by the right ventricle. The obtuse heart border separates the sterno-costal and left surfaces of the heart extending from the left atrium to the cardiac apex. (c–e) Axial CT images at the level of the inter-atrial septum (c), the proximal inter-ventricular septum (d) and the distal inter-ventricular septum (e). The atrial and ventricular septa define the septal plane. The plane defined by the atrioventricular grooves is usually perpendicular to the septal plane [11-12]. The septal plane may be marked with a line through the fat space between the right and left atria proximally, using the ruler tool on the treatment planning system. This represents the location of the interatrial septum which is usually clearly visible on CT (c). Scrolling down to the level of the ventricles this line overlies the interventricular septum and points just medial to the cardiac apex (d, e). Once the interventricular septum is located, the anterior and posterior interventricular grooves may be identified as they correspond to the anterior and posterior limits of the interventricular septum (d, e). The plane corresponding to the atrio-ventricular groove is approximately at right angles to the septal plane. The right and left atrio-ventricular grooves are usually identifiable since they are filled with fat (c–e). Abbreviations: PA: pulmonary artery, AA: ascending aorta, RA: right atrium, LA: left atrium, LV: left ventricle, RV: right ventricle.
Fig. 1 Identifying the atrioventricular and inter-ventricular grooves. (a and b) Anterior (a) and posterior (b) view of the whole heart illustrating the cardiac axis, the cardiac chambers, and the atrioventricular and inter-ventricular grooves. The cardiac axis projects through the centre of the base of the heart (the left atrium) towards the cardiac apex. The acute heart border is the horizontal heart border extending from the lower right edge of the heart to the apex, which is formed mainly by the right ventricle. The obtuse heart border separates the sterno-costal and left surfaces of the heart extending from the left atrium to the cardiac apex. (c–e) Axial CT images at the level of the inter-atrial septum (c), the proximal inter-ventricular septum (d) and the distal inter-ventricular septum (e). The atrial and ventricular septa define the septal plane. The plane defined by the atrioventricular grooves is usually perpendicular to the septal plane [11-12]. The septal plane may be marked with a line through the fat space between the right and left atria proximally, using the ruler tool on the treatment planning system. This represents the location of the interatrial septum which is usually clearly visible on CT (c). Scrolling down to the level of the ventricles this line overlies the interventricular septum and points just medial to the cardiac apex (d, e). Once the interventricular septum is located, the anterior and posterior interventricular grooves may be identified as they correspond to the anterior and posterior limits of the interventricular septum (d, e). The plane corresponding to the atrio-ventricular groove is approximately at right angles to the septal plane. The right and left atrio-ventricular grooves are usually identifiable since they are filled with fat (c–e). Abbreviations: PA: pulmonary artery, AA: ascending aorta, RA: right atrium, LA: left atrium, LV: left ventricle, RV: right ventricle.CC BY · PubMed Central
Fig. 2 Axial radiotherapy CT planning image at the level of the left ventricle inferiorly showing contouring of the coronary arterial and left ventricular myocardial segments. See Supplementary Figs. 1–3 for further images.
Fig. 2 Axial radiotherapy CT planning image at the level of the left ventricle inferiorly showing contouring of the coronary arterial and left ventricular myocardial segments. See Supplementary Figs. 1–3 for further images.CC BY · PubMed Central
Fig. 3 Coronary artery segmentation. 3D representation of the segments of the three main coronary arteries in relation to the atrial and ventricular chambers, ascending aorta and pulmonary artery. Abbreviations: PA: pulmonary artery, AA: ascending aorta, RA: right atrium, LA: left atrium, LV: left ventricle, RV: right ventricle.
Fig. 3 Coronary artery segmentation. 3D representation of the segments of the three main coronary arteries in relation to the atrial and ventricular chambers, ascending aorta and pulmonary artery. Abbreviations: PA: pulmonary artery, AA: ascending aorta, RA: right atrium, LA: left atrium, LV: left ventricle, RV: right ventricle.CC BY · PubMed Central

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Metadata

Authors
Duane, F., Aznar, M. C., Bartlett, F., Cutter, D. J., Darby, S. C., Jagsi, R., Lorenzen, E. L., McArdle, O., McGale, P., Myerson, S., Rahimi, K., Vivekanandan, S., Warren, S., & Taylor, C. W.
Affiliations
  • University of Oxford (GB)
  • Queen Alexandra Hospital (GB)
  • University of Michigan (US)
  • Odense University Hospital (DK)
  • St. Luke's Hospital (IE)
  • The George Institute for Global Health (GB)
  • University of Birmingham (GB)
Corresponding author
Duane, Frances
ORCID
Venue
Radiotherapy and Oncology
Publisher
Elsevier BV
Published
2017-03
Volume
122
Issue
3
Pages
416-422
ISSN
0167-8140 (ISSN-L)
DOI
10.1016/j.radonc.2017.01.008
PMC
PMC5356506
OpenAlex
W2591100698
Cited by
308
References
24
Citations by year
2026: 31 · 2025: 32 · 2024: 44 · 2023: 35 · 2022: 44 · 2021: 43 · 2020: 35 · 2019: 19 · 2018: 22 · 2017: 3
FWCI
20.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Radiotherapy and Oncology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
  • Research Explorer (The University of Manchester) (submittedVersion, cc-by)
Funders
  • Medical Research Council
  • Cancer Research UK (C8225/A21133, RE/13/1/30181, C5255/A15935)
  • British Heart Foundation Centre for Research Excellence
  • National Institute for Health Research
Topics
  • Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiation Dose and Imaging
Keywords
left ventricle segmentation, coronary artery segmentation, cardiac radiotherapy, breast cancer radiotherapy, heart dose
MeSH terms
Breast Neoplasms, Coronary Vessels, Female, Heart, Heart Ventricles, Humans, Radiotherapy Planning, Computer-Assisted, Tomography, X-Ray Computed

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