The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.
Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis
Abstract
This systematic review investigated the effect of paternal obesity on reproductive potential. Databases searched were Pubmed, Ovid, Web of Science, Scopus, Cinahl and Embase. Papers were critically appraised by two reviewers, and data were extracted using a standardized tool. Outcomes were: likelihood of infertility, embryo development, clinical pregnancy, live birth, pregnancy viability, infant development, sperm; concentration, morphology, motility, volume, DNA fragmentation, chromatin condensation, mitochondrial membrane potential (MMP), and seminal plasma factors. Thirty papers were included, with a total participant number of 115,158. Obese men were more likely to experience infertility (OR = 1.66, 95% CI 1.53-1.79), their rate of live birth per cycle of assisted reproduction technology (ART) was reduced (OR = 0.65, 95% CI 0.44-0.97) and they had a 10% absolute risk increase of pregnancy non-viability. Additionally, obese men had an increased percentage of sperm with low MMP, DNA fragmentation, and abnormal morphology. Clinically significant differences were not found for conventional semen parameters. From these findings it can be concluded that male obesity is associated with reduced reproductive potential. Furthermore, it may be informative to incorporate DNA fragmentation analysis and MMP assessment into semen testing, especially for obese men whose results suggest they should have normal fertility.
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“Indeed, fertility treatment is less successful in men and women who are overweight or obese as compared with normal weight couples (Campbell 2015, Rittenberg 2011).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Campbell 2015
Citations
Cites
Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050
National Center for Health Statistics (NCHS)
Feinleib, M. (2005) · Encyclopedia of Biostatistics · doi:10.1002/0470011815.b2a16042 · Cited by 3,134
Population study of causes, treatment, and outcome of infertility.
Hull, M. G., Glazener, C. M., Kelly, N. J., Conway, D. I., Foster, P. A., Hinton, R. A., Coulson, C., Lambert, P. A., Watt, E. M., & Desai, K. M. (1985) · BMJ · doi:10.1136/bmj.291.6510.1693 · Cited by 1,141
The Public Health Impact of Obesity
Visscher, T. L. S., & Seidell, J. C. (2001) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.22.1.355 · Cited by 1,031
The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996.
Swan, S. H., Elkin, E. P., & Fenster, L. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108961 · Cited by 708
McGuire, S. (2011) · Advances in Nutrition · doi:10.3945/an.111.000497 · Cited by 699
BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis
Sermondade, N., Faure, C., Fezeu, L., Shayeb, A. G., Bonde, J. P., Jensen, T. K., van Wely, M., Cao, J., Martini, A. C., Eskandar, M. A., et al. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms050 · Cited by 688
Impact of Body Mass Index Values on Sperm Quantity and Quality
Kort, H. I., Massey, J. B., Elsner, C. W., Mitchell‐Leef, D., Shapiro, D. B., Witt, M. A., & Roudebush, W. E. (2006) · Journal of Andrology · doi:10.2164/jandrol.05124 · Cited by 617
Fullston, T., Teague, E. M. C. O., Palmer, N. O., DeBlasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A., & Lane, M. (2013) · The FASEB Journal · doi:10.1096/fj.12-224048 · Cited by 600
Self-citationChavarro, J. E., Toth, T. L., Wright, D. L., Meeker, J. D., & Hauser, R. B. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.100 · Cited by 572
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1 of the 69 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Al-Ali, 2014, Body mass index has no impact on sperm quality but on reproductive hormones levels, Andrologia, 46, 106, 10.1111/and.12051 · DOI
- Jamshidi, 2011, Male obesity and sperm parameters in infertility, World Congress on Controversies in Obstetrics, Gynecology and Infertility, 14, 41
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Sorted by citations
Microbes Drive Evolution of Animals and Plants: the Hologenome Concept
ROSENBERG, E. B., & Zilber‐Rosenberg, I. (2016) · mBio · doi:10.1128/mbio.01395-15 · Cited by 525
Lifestyle causes of male infertility
Durairajanayagam, D. (2018) · Arab Journal of Urology · doi:10.1016/j.aju.2017.12.004 · Cited by 434
Niederberger, C., Pellicer, A., Cohen, J., Gardner, D. K., Palermo, G. D., O’Neill, C. L., Chow, S., Rosenwaks, Z., Cobo, A. C., Swain, J. E., et al. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.06.005 · Cited by 411
Sexual dysfunction and male infertility
Lotti, F., & Maggi, M. (2018) · Nature Reviews Urology · doi:10.1038/nrurol.2018.20 · Cited by 363
Environmental Obesogens: Mechanisms and Controversies
Heindel, J. J., & Blumberg, B. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021304 · Cited by 354
Metadata
- Authors
- Campbell, J. M., Lane, M., Owens, J. A., & Bakos, H. W.
- Affiliations
- The University of Adelaide (AU)
- Corresponding author
- Campbell, Jared M.
- Venue
- Reproductive BioMedicine Online
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 31
- Issue
- 5
- Pages
- 593-604
- ISSN
- 1472-6483 (ISSN-L)
- OpenAlex
- W2113519163
- Cited by
- 332
- References
- 69
- Citations by year
- 2026: 19 · 2025: 20 · 2024: 23 · 2023: 47 · 2022: 39 · 2021: 48 · 2020: 25 · 2019: 39 · 2018: 26 · 2017: 31 · 2016: 13 · 2015: 1
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive BioMedicine Online (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- paternal obesity, male infertility, assisted reproduction outcomes, live birth rate, miscarriage, sperm DNA fragmentation, mitochondrial membrane potential, sperm morphology, semen parameters, male reproductive potential
- MeSH terms
- Female, Fertility, Humans, Infertility, Male, Male, Obesity, Pregnancy, Sperm Motility, Spermatozoa, Reproductive Techniques, Assisted, DNA Fragmentation, Semen Analysis
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