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The safety of calcium channel blockers during pregnancy: A prospective, multicenter, observational study
Abstract
Objective To assess the safety of calcium channel blockers during the first trimester of pregnancy.Study design A multicenter (n=11), prospective observational study of the European Network of Teratology Information Services (ENTIS). The rate of major birth defects was compared between a cohort of pregnant women exposed to calcium channel blockers during the first trimester (n=299) and a control group not exposed to potential teratogens (n=806).Results Major birth defects were not more common in the study group than in the control group. Birth weight was significantly lower in exposed term newborns. There were more preterm infants in the study group than in the control group (23.8% vs. 6.5%). These adverse effects are more likely due to the underlying disease than to the medication.Conclusion This study suggests that calcium channel blockers during the first trimester of pregnancy do not represent a major teratogenic risk.
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“Among the calcium channel blockers the experience is greatest with verapamil which overall appear to be relatively safe.405”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [405]
Citations
Cites
Martindale: the complete drug reference
(2005) · Choice Reviews Online · doi:10.5860/choice.42-6228 · Cited by 2,684
Guidelines for case classification for the national birth defects prevention study
Rasmussen, S. A., Olney, R. S., Holmes, L. B., Lin, A. E., Keppler‐Noreuil, K. M., & Moore, C. A. (2003) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.10012 · Cited by 581
Vitamin K antagonists and pregnancy outcome
Hannemann, D., Meister, R., Éléfant, É., Paulus, W. E., Vial, T., Reuvers, M., Robert‐Gnansia, E., Arnon, J., Santis, M. D., Clementi, M., et al. (2006) · Thrombosis and Haemostasis · doi:10.1160/th06-02-0108 · Cited by 208
The safety of calcium channel blockers in human pregnancy: A prospective, multicenter cohort study
Magee, L. A., Schick, B., Donnenfeld, A. E., Sage, S. R., Conover, B., Cook, L. P., McElhatton, P. R., Schmidt, M. A., & Koren, G. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70307-1 · Cited by 202
Phenotypic abnormalities: Terminology and classification
Merks, J. H. M., van Karnebeek, C., Caron, H. N., & Hennekam, R. C. M. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.20249 · Cited by 118
Simán, C. M., Groot, A. C. G., Wisse, B., & Eriksson, U. J. (2000) · Teratology · doi:10.1002/(sici)1096-9926(200005)61:5 · Cited by 96
Post-marketing surveillance system for drugs in pregnancy—15 years experience of ENTIS
Schaefer, C., Hannemann, D., & Meister, R. (2005) · Reproductive Toxicology · doi:10.1016/j.reprotox.2005.03.012 · Cited by 63
Danielsson, B. R. G., Reiland, S., Rundqvist, E., & Danielson, M. (1989) · Teratology · doi:10.1002/tera.1420400407 · Cited by 62
Sørensen, H. T., Czeizel, A. E., Rockenbauer, M., Steffensen, F. H., & Olsen, J. (2001) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2001.d01-4.x · Cited by 46
Pathogenesis of retinoic acid-induced ear malformations in a primate model
Wei, X. P., Makori, N., Peterson, P. E., Hummler, H., & Hendrickx, A. G. (1999) · Teratology · doi:10.1002/(sici)1096-9926(199908)60:2 · Cited by 45
Research works printed but not linked: 3
- Sørensen, 1998, Pregnancy outcome in women exposed to calcium channel blockers, Reprod Toxicol, 12, 383
- Tabacova, 2002, Developmental abnormalities reported to FDA in association with nifedipine treatment in pregnancy, Teratology, 65, 368
- Yoshida, 1989, Hyperphalangism induced by Ca-blockers in rat fetuses, Teratology, 40, 668
Cited by
Sorted by citations
2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomström-Lundqvist, C., Cífková, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy340 · Cited by 2,292
ESC Guidelines on the management of cardiovascular diseases during pregnancy
Endorsed by the European Society of Gynecology (ESG), T. A. F. E. P. C. (., Authors/Task Force Members, Regitz-Zagrosek, V., Blomstrom Lundqvist, C., Borghi, C., Cifkova, R., Ferreira, R., Foidart, J.-M., Gibbs, J. S. R., Gohlke-Baerwolf, C., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr218 · Cited by 1,924
Evolving knowledge of the teratogenicity of medications in human pregnancy
Adam, M. P., Polifka, J. E., & Friedman, J. M. (2011) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30313 · Cited by 381
“…2001; Kubicsek et al., 2010; Boyd et al., 2011], and many prospective exposure cohort studies of pregnancy outcomes following treatment with prescription medications have been performed through teratology information services [Weber-Schoendorfer et al., 2008; Hancock et al., 2010; Chambers, 2011].”
BackgroundUse of Medication for Cardiovascular Disease During Pregnancy
Halpern, D. G., Weinberg, C. R., Pinnelas, R., Mehta‐Lee, S. S., Economy, K. E., & Valente, A. M. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.10.075 · Cited by 322
Katritsis, D. G., Boriani, G., Cosio, F. G., Hindricks, G., Jaïs, P., Josephson, M. E., Keegan, R., Kim, Y.-H., Knight, B. P., Kuck, K.-H., et al. (2017) · Europace · doi:10.1093/europace/euw301 · Cited by 188
Lee, L. J., & Lupo, P. J. (2012) · Pediatric Cardiology · doi:10.1007/s00246-012-0470-x · Cited by 187
Tamirisa, K. P., Elkayam, U., Briller, J. E., Mason, P. K., Pillarisetti, J., Merchant, F. M., Patel, H. N., Lakkireddy, D. R., Russo, A. M., Volgman, A. S., et al. (2021) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2021.10.004 · Cited by 154
Kidney stones during pregnancy
Semins, M. J., & Matlaga, B. R. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2014.17 · Cited by 125
Paper 6: EUROCAT member registries: Organization and activities
Greenlees, R., Neville, A. J., Addor, M., Amar, E., Arriola, L., Bakker, M. K., Barišić, I., Boyd, P. A., Calzolari, E., Doray, B., et al. (2011) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20775 · Cited by 123
Ramakrishnan, A., Lee, L. J., Mitchell, L. E., & Agopian, A. J. (2015) · Pediatric Cardiology · doi:10.1007/s00246-015-1182-9 · Cited by 103
Use of medication for cardiovascular disease during pregnancy
Pieper, P. G. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.172 · Cited by 82
“However, later largescale studies did not reproduce the finding (60,61).”
ResultHypertensive Disorders of Pregnancy
Shah, S., & Gupta, A. (2019) · Cardiology Clinics · doi:10.1016/j.ccl.2019.04.008 · Cited by 81
In-utero exposure to antihypertensive medication and neonatal and child health outcomes
Fitton, C. A., Steiner, M. F. C., Aucott, L. S., Pell, J. P., Mackay, D., Fleming, M., & McLay, J. S. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001456 · Cited by 80
“[24], in a cohort study of 1105 women rated as poor, reported increased odds of preterm birth (adjusted OR 4.”
BackgroundInfluentialOhya, Y., Arakawa, K., Arata, N., Arima, S., Arima, H., Asayama, K., Dohi, Y., Fukami, A., Furuhashi, M., Goto, K., et al. (2026) · Hypertension Research · doi:10.1038/s41440-025-02462-y · Cited by 83
van Gelder, M. M. H. J., Bennekom, C. M. V., Louik, C., Werler, M. M., Roeleveld, N., & Mitchell, A. A. (2014) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.13138 · Cited by 73
Management of type 1 diabetes in pregnancy
Feldman, A. Z., & Brown, F. M. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0765-z · Cited by 65
Pulmonary Arterial Hypertension in Pregnancy
Ballard, W., Dixon, B., McEvoy, C. A., & Verma, A. (2020) · Cardiology Clinics · doi:10.1016/j.ccl.2020.09.007 · Cited by 60
Perinatal Outcomes with Tamsulosin Therapy for Symptomatic Urolithiasis
Bailey, G. L., Vaughan, L. E., Rose, C. H., & Krambeck, A. E. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.06.097 · Cited by 56
Management of urolithiasis in pregnancy
Matlaga, B. R., & Semins, M. J. (2013) · International Journal of Women s Health · doi:10.2147/ijwh.s51416 · Cited by 55
“Gestational hypertension and preterm labor are often treated with calcium channel blockers and these are also thought to be safe.(62) Similar to the general population, some patients are not candidates for trial of passage and some fail conservative management.”
Arrhythmias in Female Patients: Incidence, Presentation and Management
Zeitler, E. P., Poole, J. E., Albert, C. M., Al-Khatib, S. M., Ali-Ahmed, F., Birgersdotter-Green, U., Cha, Y.-M., Chung, M. K., Curtis, A. B., Hurwitz, J. L., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.319893 · Cited by 57
Safety of Amlodipine in Early Pregnancy
Mito, A., Murashima, A., Wada, Y., Miyasato‐Isoda, M., Kamiya, C., Waguri, M., Yoshimatsu, J., Yakuwa, N., Watanabe, O., Suzuki, T., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012093 · Cited by 54
“The use of antihypertensives in the fi rst trimester has generally been found not to increase the risk of morphologic abnormalities in offspring, 3,4,12 – 16 although studies exist showing potential associations with birth defects such as heart malformation, 6,17 – 19 hypospadias, 20,21 and central…”
Complicated Urinary Tract Infections
Augustin, G. (2023) · Springer eBooks · doi:10.1007/978-3-031-26021-6_27 · Cited by 45
Maternal cardiac arrhythmias during pregnancy and lactation
Cordina, R., & McGuire, M. A. (2010) · Obstetric Medicine · doi:10.1258/om.2009.090021 · Cited by 45
Pregnancy and pulmonary arterial hypertension: A clinical conundrum
Sahni, S., Palkar, A. V., Rochelson, B. L., Kępa, W., & Talwar, A. (2015) · Pregnancy Hypertension · doi:10.1016/j.preghy.2015.01.004 · Cited by 37
“The use of calcium channel during the first trimester of pregnancy seems not to represent a major teratogenic risk [22].”
BackgroundManagement of envenomations during pregnancy
Brown, S. A., Seifert, S. A., & Rayburn, W. F. (2013) · Clinical Toxicology · doi:10.3109/15563650.2012.760127 · Cited by 36
Pregnancy in women with congenital heart disease
Cauldwell, M., Santos, F. D., Steer, P. J., Swan, L., Gatzoulis, M. Α., & Johnson, M. R. (2018) · BMJ · doi:10.1136/bmj.k478 · Cited by 35
Yin, J., Mei, Z., Shi, S., Du, P., & Qin, S. (2022) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-022-06504-5 · Cited by 31
Migraine therapy during pregnancy and lactation
Cassina, M., Gianantonio, E. D., Toldo, I., Battistella, P. A., & Clementi, M. (2010) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2010.505601 · Cited by 29
“Most studies involving pregnant women exposed to a calcium channel blocker, mainly nifedipine and verapamil, however, have not reported an increase in infant malformations [85-88].”
BackgroundIshikawa, T., Nishigori, H., Akazawa, M., Miyakoda, K., Noda, A., Ishikuro, M., Metoki, H., Iwama, N., Saito, M., Sugawara, J., et al. (2023) · Pregnancy Hypertension · doi:10.1016/j.preghy.2023.01.001 · Cited by 29
Hypertensive Disorders in Pregnancy
Shah, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-25324-0_2 · Cited by 27
Taufield, P. A., Müller, F., & Laragh, J. H. (1986) · Springer eBooks · doi:10.1007/978-94-009-4271-4_7 · Cited by 28
Stones in pregnancy and pediatrics
Bjazevic, J., & RAZVI, H. A. (2018) · Asian journal of urology · doi:10.1016/j.ajur.2018.05.006 · Cited by 24
“These medications are currently classed as a category B medication in pregnancy and thought to be safe with no harmful effects having been demonstrated in humans [42].”
BackgroundIzarzugaza, J. M. G., Ellesøe, S. G., Doğanlı, C., Ehlers, N. S., Dalgaard, M., Audain, E., Dombrowsky, G., Banasik, K., Sifrim, A., Wilsdon, A., et al. (2020) · Genome Medicine · doi:10.1186/s13073-020-00772-z · Cited by 23
Safety of Antihypertensive Medications in Pregnancy: Living With Uncertainty
Malha, L. P., & August, P. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013495 · Cited by 23
“widely prescribed antihypertensive medications for nonpregnant individuals; however, before the study by Mito and colleagues, only limited data (<50 cases) regarding safety in pregnancy were available.(8,9) Mito and colleagues retrospectively examined birth outcomes of 231 pregnant women with chronic hypertension who…”
BackgroundManagement of ureteric stone in pregnancy: a review
Thakur, A. P. S., Sharma, V., Ramasamy, V., Choudhary, A., Patel, P., Singh, S., & Parol, S. (2020) · African Journal of Urology · doi:10.1186/s12301-020-00070-5 · Cited by 22
Hallmarks of primary headache: part 3 – cluster headache
Coppola, G., Arruda, M. A., Ashina, M., Barloese, M. C. J., Belin, A. C., Bottiroli, S., Chowdhury, D., Icco, R. D., Lorenzo, C. D., Stefano, G. D., et al. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-02145-6 · Cited by 20
Fisher, S. C., Zutphen, A. R. V., Werler, M. M., Romitti, P. A., Cunniff, C. M., Browne, M. L., & Study, T. N. B. D. P. (2018) · Birth Defects Research · doi:10.1002/bdr2.1372 · Cited by 22
Wiles, K., & Lightstone, L. (2018) · Kidney International Reports · doi:10.1016/j.ekir.2018.01.010 · Cited by 19
Pregnancy Arrhythmias: Management in the Emergency Department and Critical Care
Conti, E., Cascio, N. D., Paluan, P., Racca, G., Longhitano, Y., Savioli, G., Tesauro, M., Leo, R., Racca, F., & Zanza, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041095 · Cited by 16
“Atenolol is the only beta - blocker listed in FDA Class D due to increased risk of congenital malformations [53–58].”
BackgroundPrejbisz, A., Dobrowolski, P., Kosiński, P., Bomba-Opon, D. A., Adamczak, M., Bekiesińska‐Figatowska, M., Kądziela, J., Konopka, A., Kostka-Jeziorny, K., Kurnatowska, I., et al. (2019) · Arterial Hypertension · doi:10.5603/ah.a2019.0011 · Cited by 15
Management of urolithiasis in pregnancy: A systematic review and meta-analysis
Salehi‐Pourmehr, H., Tayebi, S., DalirAkbari, N., Ghabousian, A., Tahmasbi, F., Rahmati, F., Naseri, A., HajEbrahimi, R., Mehdipour, R., Hemmati-Ghavshough, M., et al. (2023) · Scandinavian Journal of Surgery · doi:10.1177/14574969221145774 · Cited by 14
In Utero Antihypertensive Medication Exposure and Neonatal Outcomes
Fitton, C. A., Fleming, M., Steiner, M. F. C., Aucott, L. S., Pell, J. P., Mackay, D., & McLay, J. S. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13802 · Cited by 14
Romão, M. A. W., Pinto, L., Cavalli, R. D. C., Duarte, G. G., de Moraes, N. V., Abduljalil, K., & Moreira, F. D. L. (2024) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.2404 · Cited by 11
Mukherjee, M. S., Coppenrath, V. A., & Dallinga, B. A. (2015) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1535 · Cited by 10
“Another study of the European Network of Teratogen Information Services enrolled women who contacted the services with questions regarding first-trimester exposure to CCBs between 1986 and 2003.(66) These 299 women were matched to 806 controls from the same country and birth year who had received counseling about expo…”
BackgroundPharmacotherapy for hypertension in pregnant patients: special considerations
Tamargo, J. L., Caballero, R., & Delpón, E. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1594773 · Cited by 14
“α/β-blockers or centrally-acting adrenergic agents [88–93], calcium channel blockers (CCBs) [89,90,94,95] and methyldopa”
BackgroundBjørk, M., Kristoffersen, E. S., Tronvik, E., & Nordeng, H. (2021) · European Journal of Neurology · doi:10.1111/ene.14864 · Cited by 10
“In small observational studies in patients with cardiovascular disorders, and in a systematic review, verapamil was not associated with an increased risk of fetal malformations [32,54].”
BackgroundChronic Hypertension and Pregnancy
August, P., & Lindheimer, M. D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374213-1.00019-7 · Cited by 9
Malha, L. P., Podymow, T., & August, P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-88369-6.00044-x · Cited by 9
Ritchie, H. E., Telenius, C., Gustaffson, E., & Webster, W. S. (2019) · Birth Defects Research · doi:10.1002/bdr2.1457 · Cited by 9
Chou, C., Lee, H., Wo, H.-T., Chang, P., Chiang, C.-Y., Chiu, K.-P., & Liu, H.-T. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.10.011 · Cited by 9
Cardiovascular Drugs in Pregnancy and Lactation
Pieper, P. G., Elkayam, U., Eskandar, J., & Ruys, T. P. E. (2019) · Wiley eBooks · doi:10.1002/9781119409861.ch32 · Cited by 8
Katritsis, D. G., Boriani, G., Cosío, F. G., Jaı̈s, P., Hindricks, G., Josephson, M. E., Keegan, R., Knight, B. P., Kück, K., Lane, D. A., et al. (2016) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2016:5.3.gl1 · Cited by 7
Arzneimitteltherapiesicherheit in der Schwangerschaft – das Embryotox-Projekt
Schaefer, C., Oppermann, M., Wacker, E., & Weber‐Schoendorfer, C. (2012) · Zeitschrift für Evidenz Fortbildung und Qualität im Gesundheitswesen · doi:10.1016/j.zefq.2012.11.012 · Cited by 7
Current approach for urinary system stone disease in pregnant women
Çelik, O., Türk, H., Çakmak, Ö., Ekin, R. G., Keskin, M. Z., Yıldız, G., & İlbey, Y. Ö. (2016) · Archivio Italiano di Urologia e Andrologia · doi:10.4081/aiua.2015.4.280 · Cited by 7
“As a part of MET, alpha blockers and calcium channel blockers can be safely used during pregnancy (75).”
BackgroundThe importance and safety of calcium antagonists in the treatment of hypertension in pregnant women
Grześk, G., Wołowiec, Ł., Walukiewicz, M., Rogowicz, D., Gilewski, W., & Banach, J. (2019) · Pregnancy Hypertension · doi:10.1016/j.preghy.2019.03.001 · Cited by 6
Disturbed intracellular calcium homeostasis in neural tube defects in diabetic embryopathy
Zhao, Z., Cao, L., Hernández‐Ochoa, E. O., Schneider, M. F., & Reece, E. A. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.067 · Cited by 6
“Treatments with Ca2+ channel blockers during early pregnancy have not been found to increase teratogenic risk [33,34].”
BackgroundManagement of Urolithiasis in Pregnancy
Alenezi, H., & Denstedt, J. D. (2018) · doi:10.1002/9781119245193.ch65 · Cited by 6
Webster, L., Webb, A. J., & Chappell, L. C. (2018) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2018.9.000008 · Cited by 5
Hypertension in pregnancy: classification, diagnosis and treatment
Katsiki, N., Godosis, D., Komaitis, S., & Hatzitolios, A. I. (2010) · Aristotle University Medical journal/Aristotle University Medical Journal · Cited by 5
Drugs in renal disease and pregnancy
Sarwar, A. (2019) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2019.03.006 · Cited by 9
Malha, L. P., Podymow, T., & August, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42973-3.00039-1 · Cited by 5
Management of Urolithiasis in Pregnancy
Bjazevic, J., & Denstedt, J. D. (2019) · Springer eBooks · doi:10.1007/978-3-030-26649-3_13 · Cited by 4
Winterfeld, U., Weber‐Schoendorfer, C., Schaefer, C., von Elm, E. B., & Buclin, T. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.06.002 · Cited by 4
Pregnancy in heart transplant recipients – current perspectives
Watson, W. D., Bhagra, S. K., & Bhagra, C. (2019) · Transplant Research and Risk Management · doi:10.2147/trrm.s188281 · Cited by 4
“Diltiazem has limited human data and is FDA category C however teratogenicity has only been shown in animal studies.(34) Dihydropyridine CCB can be continued.”
Teratogenicity study in rats of commonly used calcium channel blockers
Jaiswal, S., Bhardwaj, D., & Brashier, D. B. S. (2019) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20195282 · Cited by 3
Umans, J. G., Abalos, E. J., & Lindheimer, M. D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374213-1.00020-3 · Cited by 3
Antihypertensive drug prescription pattern before and during pregnancy in France
Duhalde, V., Hurault‐Delarue, C., Lacroix, I., Suarez, C., Bourrel, R., Montastruc, J., & Damase‐Michel, C. (2011) · Pregnancy Hypertension · doi:10.1016/j.preghy.2011.01.001 · Cited by 4
“Calcium channel blockers, during the first trimester of pregnancy, do not represent a major teratogenic risk [23], and their use later in pregnancy is widespread and reassuring.”
BackgroundImpact of tamsulosin and nifedipine on contractility of pregnant rat ureters in vitro
Haddad, L., Corriveau, S., Rousseau, É., Blouin, S., Pasquier, J., Ponsot, Y., & Roy‐Lacroix, M. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1280017 · Cited by 3
Fetal Effects of Drugs Commonly Used in Critical Care
Santillan, M. K., & Yankowitz, J. (2010) · Wiley eBooks · doi:10.1002/9781444316780.ch44 · Cited by 3
Cardiac Disease in Pregnancy: Hypertrophic Obstructive Cardiomyopathy and Pulmonic Stenosis.
Arnolds, D., Dean, C., Minhaj, M. M., Schnettler, W., Banayan, J., & Chaney, M. (2021) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2021.03.033 · Cited by 3
Sadeghi, M. R., Aslanabadi, N., Aghdam, N. K., Parizad, R., & Namdar, H. (2014) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2014.43 · Cited by 2
“If necessary, non dihydropyridine calcium channel blockers may be used (38-41).”
BackgroundVentricular tachycardia and pregnancy
Schenkelaars, N., Kauling, R. M., Ramlakhan, K. P., Yap, S., Cornette, J. M. J., & Roos‐Hesselink, J. W. (2021) · International Journal of Cardiology Congenital Heart Disease · doi:10.1016/j.ijcchd.2021.100284 · Cited by 2
Antihypertensives in Pregnancy
Denoble, A. E., Goldstein, S. A., & Pettker, C. M. (2023) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2022.10.008 · Cited by 2
Therapeutic role of nifedipine in threatened preterm labor: Current evidence and future perspectives
Imatake, H., Chigusa, Y., Mogami, H., Morita, S., & Mandai, M. (2026) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70816 · Cited by 1
Habal, R. (2010) · Elsevier eBooks · doi:10.1016/b978-0-323-05472-0.00178-x · Cited by 1
Special Conditions in Urinary Lithiasis
AL-Mamari, S. A. (2017) · In clinical practice · doi:10.1007/978-3-319-62437-2_12 · Cited by 1
Umans, J. G., Abalos, E. J., & Cunningham, F. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407866-6.00019-5 · Cited by 1
Augustin, G. (2018) · Springer eBooks · doi:10.1007/978-3-319-72995-4_20 · Cited by 1
Impact of medical conditions and medications received during pregnancy on adverse birth outcomes
Undela, K., Parthasarathi, G., & Sujatha, M. S. (2021) · Perspectives in Clinical Research · doi:10.4103/picr.picr_16_21 · Cited by 1
“However, the authors contend that these ABOs are more likely due to the underlying medical conditions than to the medication.[23]”
BackgroundVianna, F. S. L., Schüler‐Faccini, L., & Weber-Schöndorfer, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408078-2.00009-3 · Cited by 1
Advances in pharmacological treatment of type 1 diabetes during pregnancy
Patti, A. M., Giglio, R. V., Pafili, K., Rizzo, M., & Παπάνας, Ν. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1593372 · Cited by 2
“Before conception, BP control can be achieved with methyldopa, calcium channel blockers [50] or labetalol [51].”
BackgroundChronic Hypertension and Pregnancy
August, P., Jeyabalan, A., & Roberts, J. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407866-6.00018-3 · Cited by 1
Medication Use During Pregnancy in the Intensive Care Unit
Ornoy, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-43477-9_38 · Cited by 1
Maternal Cardiomyopathy and Critical Care Medicine
Cobb, B. T., & Harker, E. (2020) · Springer eBooks · doi:10.1007/978-3-030-43477-9_11 · Cited by 1
Spezielle Arzneimitteltherapie in der Schwangerschaft
(2012) · Elsevier eBooks · doi:10.1016/b978-3-437-21203-1.10002-0 · Cited by 1
Litiasis Renal en pacientes gestantes: diagnóstico y manejo
Ontaneda, J. F. B., & Castro, A. S. B. (2023) · Salud ConCiencia · doi:10.55204/scc.v2i2.e39 · Cited by 1
Fetal Effects of Drugs Commonly Used in Critical Care
Običan, S. G., & Yankowitz, J. (2018) · Wiley eBooks · doi:10.1002/9781119129400.ch9 · Cited by 1
Carlier, P., Caron, J., Gautier, S., Lagarce, L., Lainé‐Cessac, P., & Vial, T. (2012) · Elsevier eBooks · doi:10.1016/b978-2-294-70624-0.00017-9
Special Issues in Managing Migraine in Women: AReview Article
Myint, A. A., Loh, N. K., & Aung, Z. Z. (2013) · International journal of collaborative research on internal medicine & public health
Atrial fibrillation and supraventricular arrhythmias
Katritsis, D. G., & Camm, A. J. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198849346.003.0054
Maternal Use of Drugs for Cardiovascular Diseases and Infant Congenital Malformations
Källén, B. A. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-17898-7_9
Haque, N., Hosain, N., Islam, A. M., Mamataz, Z., Ibrahim, M., Ahmed, S., Anisuzzaman, M., & Akter, S. (2021) · Cardiovascular Journal · doi:10.3329/cardio.v14i1.55376
Current awareness in prenatal diagnosis
(2009) · Prenatal Diagnosis · doi:10.1002/pd.2097
Current awareness: Pharmacoepidemiology and drug safety
(2009) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1645
Serie guías clínicas: manejo de la hipertensión crónica en el embarazo
Sepúlveda-Martínez, Á., Erico Segovia, R., & Parra-Cordero, M. (2023) · Revista Hospital Clínico Universidad de Chile · doi:10.5354/2735-7996.2017.70606
Uncommon Cardiac Dysrhythmias in Pregnancy
Agaram, R., & Davidson, M. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009070256.006
Fetal Effects of Drugs Commonly Used in Critical Care
Kendle, A. M., & Običan, S. G. (2024) · Wiley eBooks · doi:10.1002/9781119820260.ch9
AAD in Women and During Pregnancy
Ascoeta, S., Caixal, G., Arbelo, E., & López, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-74046-6_15
Arrhythmias in Pregnancy: A Comprehensive Review
Ahmad, R., Frishman, W. H., & Aronow, W. S. (2025) · Cardiology in Review · doi:10.1097/crd.0000000000001031
Metadata
- Authors
- Weber-Schoendorfer, C., Hannemann, D., Meister, R., Eléfant, E., Cuppers-Maarschalkerweerd, B., Arnon, J., Vial, T., Rodriguez-Pinilla, E., Clementi, M., Robert-Gnansia, E., De Santis, M., Malm, H., Dolivo, A., & Schaefer, C.
- Affiliations
- Berliner Hochschule für Technik (DE)
- Israel Ministry of Health (IL)
- Hospices Civils de Lyon (FR)
- University of Padua (IT)
- Venue
- Reproductive Toxicology
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 26
- Issue
- 1
- Pages
- 24-30
- ISSN
- 0890-6238 (ISSN-L)
- OpenAlex
- W2027351405
- Cited by
- 104
- References
- 15
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 18 · 2018: 10 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Bundesinstitut für Arzneimittel und Medizinprodukte
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- calcium channel blockers, pregnancy, first trimester, teratogenicity, congenital malformations, birth weight, preterm birth, drug safety in pregnancy
- MeSH terms
- Abnormalities, Drug-Induced, Abortion, Spontaneous, Adolescent, Adult, Birth Weight, Calcium Channel Blockers, Europe, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Israel, Middle Aged, Pregnancy, Pregnancy Trimester, First, Prospective Studies, Premature Birth
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