Tissue Distribution of 35S-Labelled Perfluorooctane Sulfonate (PFOS) in C57Bl/6 Mice Following Late Gestational Exposure
Abstract
Exposure of rodents in utero to perfluorooctane sulfonate (PFOS) impairs perinatal development and survival. Following intravenous or gavage exposure of C57Bl/6 mouse dams on gestational day (GD) 16 to (35)S-PFOS (12.5mg/kg), we determined the distribution in dams, fetuses (GD18 and GD20) and pups (postnatal day 1, PND1) employing whole-body autoradiography and liquid scintillation counting. In dams, levels were highest in liver and lungs. After placental transfer, (35)S-PFOS was present on GD18 at 2-3 times higher levels in lungs, liver and kidneys than in maternal blood. In PND1 pups, levels in lungs were significantly higher than in GD18 fetuses. A heterogeneous distribution of (35)S-PFOS was observed in brains of fetuses and pups, with levels higher than in maternal brain. This first demonstration of substantial localization of PFOS to both perinatal and adult lungs is consistent with evidence describing the lung as a target for the toxicity of PFOS at these ages.
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More PFAS penetrates to the brain tissue of experimental animals after developmental exposure, in comparison to adult exposures.
“More PFAS penetrates to the brain tissue of experimental animals after developmental exposure, in comparison to adult exposures (Chang et al., 2009; Borg et al., 2010; Ishida et al., 2017).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Borg et al., 2010
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References 54 · Cited by 76
- Authors
- Borg, D., Bogdanska, J., Sundström, M., Nobel, S., Håkansson, H., Bergman, Å., DePierre, J. W., Halldin, K., & Bergström, U.
- Affiliations
- Karolinska Institutet (SE)
- Stockholm University (SE)
- Uppsala University (SE)
- Corresponding author
- Bergström, U.
- Venue
- Reproductive Toxicology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 30
- Issue
- 4
- Pages
- 558-565
- ISSN
- 0890-6238 (ISSN-L)
- OpenAlex
- W2018591330
- Cited by
- 76
- References
- 54
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Svenska Forskningsrådet Formas
- Stockholms Universitet
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- PFOS, tissue distribution, prenatal exposure, placental transfer, fetal development, perinatal development, lung, brain, liver, kidney, perfluorinated compounds, developmental toxicity, C57BL/6 mice
- MeSH terms
- Animals, Animals, Newborn, Brain, Environmental Pollutants, Female, Fetal Blood, Fetus, Fluorocarbons, Kidney, Liver, Lung, Maternal-Fetal Exchange, Mice, Inbred C57BL, Pregnancy, Scintillation Counting, Sulfur Radioisotopes, Tissue Distribution, Alkanesulfonic Acids, Maternal Exposure, Mice, Whole Body Imaging
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