Antibiotic resistance, virulence factors and genetics of Clostridium sordellii.
Open accessAbstract
Clostridium sordellii is gram positive bacterial pathogen of humans and animals. While the incidence of human-related C. sordellii infection is low, the mortality rate associated with infection is high. Of particular concern are C. sordellii infections after child-birth or medical abortion, which have an almost 100% mortality rate. Recent genetic and epidemiological work has increased our understanding of how this pathogen has evolved and how it causes disease. This review will summarise studies involving the genetics of C. sordellii, including an antibiotic resistance profile, the genetic determinants of virulence and mutagenesis of C. sordellii.
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Most strains of P. sordellii do not produce TscL or TscH toxins but are pathogenic and have been associated with necrotizing gastroenteric disease, toxicosis, and mortality in horses, cattle, sheep, dogs, lions, and chickens.
“Most strains of P. sordellii do not produce TscL or TscH toxins but are pathogenic (Vidor et al., 2015) and have been associated with necrotizing gastroenteric disease, toxicosis, and mortality in horses, cattle, sheep, dogs, lions, and chickens (Lewis and Naylor, 1998;de la Fe et al., 2006;Rimoldi et al., 2015;Capewell et al., 2020).”
From Novel Lethal Clostridial Infection in Florida Manatees (Trichechus manatus latirostris): Cause of the 2013 Unusual Mortality Event in the Indian River Lagoon (2022) · cites this paper as Vidor et al., 2015
In P. sordellii strain FL-manatee, the gene ORF_03500 was predicted to encode phospholipase C (CpPLC), which is homologous to C. perfringens alpha toxin but displays lower enzymatic and hemolytic activity.
“In P. sordellii strain FL-manatee, the gene ORF_03500 was predicted to encode phospholipase C (CpPLC), which is homologous to C. perfringens alpha toxin but displays lower enzymatic and hemolytic activity (Vidor et al., 2015).”
From Novel Lethal Clostridial Infection in Florida Manatees (Trichechus manatus latirostris): Cause of the 2013 Unusual Mortality Event in the Indian River Lagoon (2022) · cites this paper as Vidor et al., 2015
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Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance
Connell, S. R., Tracz, D. M., Nierhaus, K. H., & Taylor, D. E. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.12.3675-3681.2003 · Cited by 449 · see citing works
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Landsberg, J. H., Tabuchi, M., Rotstein, D. S., Subramaniam, K., Rodrigues, T. C. S., Waltzek, T. B., Stacy, N. I., Wilson, P. W., Kiryu, Y., Uzal, F. A., et al. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.841857 · Cited by 20 · see citing works
- Authors
- Vidor, C., Awad, M., & Lyras, D.
- Affiliations
- Monash University (AU)
- Corresponding author
- Lyras, Dena
- Venue
- Research in Microbiology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 166
- Issue
- 4
- Pages
- 368-374
- ISSN
- 0769-2609 (ISSN-L)
- 0923-2508
- OpenAlex
- W1969988690
- Cited by
- 56
- References
- 1
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 2
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Research in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Diphtheria, Corynebacterium, and Tetanus
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- Clostridium sordellii, antibiotic resistance, virulence factors, bacterial genetics, postpartum infection, abortion pills, bacterial evolution, mutagenesis
- MeSH terms
- Animals, Clostridium Infections, Humans, Incidence, Survival Analysis, Drug Resistance, Bacterial, Virulence Factors, Clostridium sordellii, Paraclostridium sordellii
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