Effects of nitrate supplementation via beetroot juice on contracting rat skeletal muscle microvascular oxygen pressure dynamics
Open accessAbstract
NO3(-) supplementation via beetroot juice (BR) augments exercising skeletal muscle blood flow subsequent to its reduction to NO2(-) then NO. We tested the hypothesis that enhanced vascular control following BR would elevate the skeletal muscle O2 delivery/O2 utilization ratio (microvascular PO2, PmvO2) and raise the PmvO2 during the rest-contractions transition. Rats were administered BR (~0.8 mmol/kg/day, n=10) or water (control, n=10) for 5 days. PmvO2 was measured during 180 s of electrically induced (1 Hz) twitch spinotrapezius muscle contractions. There were no changes in resting or contracting steady-state PmvO2. However, BR slowed the PmvO2 fall following contractions onset such that time to reach 63% of the initial PmvO2 fall increased (MRT1; control: 16.8±1.9, BR: 24.4±2.7 s, p<0.05) and there was a slower relative rate of PmvO2 fall (Δ1PmvO2/τ1; control: 1.9±0.3, BR: 1.2±0.2 mmHg/s, p<0.05). Despite no significant changes in contracting steady state PmvO2, BR supplementation elevated the O2 driving pressure during the crucial rest-contractions transients thereby providing a potential mechanism by which BR supplementation may improve metabolic control.
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Nitrate supplementation, which may reduce both the ATP and oxygen cost of muscle contraction, simultaneously increases muscle oxygen delivery.
“Those studies [71, 72] indicate that nitrate supplementation, which may reduce both the ATP and oxygen cost of muscle contraction [41, 59, 61], simultaneously increases muscle oxygen delivery.”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [72]
In rats fed beetroot juice, microvascular oxygen pressure falls less rapidly following the onset of electrically evoked contractions of the spinotrapezius muscle compared with those fed water.
“In a subsequent study, the same authors reported that microvascular oxygen pressure fell less rapidly following the onset of electrically evoked contractions of the spinotrapezius muscle of rats fed beetroot juice compared with those fed water [72].”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [72]
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References 42 · Cited by 69
- Authors
- Ferguson, S. K., Hirai, D. M., Copp, S. W., Holdsworth, C. T., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C.
- Affiliations
- Kansas State University (US)
- Duke University (US)
- University of Exeter (GB)
- Corresponding author
- Poole, David C.
- ORCID
- Venue
- Respiratory Physiology & Neurobiology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 187
- Issue
- 3
- Pages
- 250-255
- ISSN
- 1569-9048 (ISSN-L)
- PMC
- PMC3753182
- OpenAlex
- W2130822288
- Cited by
- 69
- References
- 42
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 2
- FWCI
- 20.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Respiratory Physiology & Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- Funders
- University of Kansas
- National Heart, Lung, and Blood Institute (HL-108328, R15HL108328)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- beetroot juice, nitrate supplementation, muscle contraction, spinotrapezius muscle, nitric oxide, nitrite, muscle blood flow, vascular regulation
- MeSH terms
- Animals, Beverages, Blood Gas Analysis, Blood Pressure, Heart Rate, Male, Microcirculation, Muscle Contraction, Nitrates, Oxygen, Oxygen Consumption, Rats, Sprague-Dawley, Muscle, Skeletal, Dietary Supplements, Beta vulgaris, Rats
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