Sex differences in the quality-of-life and functional outcome of cardiac arrest survivors
Abstract
Aim Although survival from out-of-hospital cardiac arrest (OHCA) is improving, little is known about the long-term outcome of survivors. In this study, we assess the impact of sex on 12 month functional recovery and health-related quality-of-life (HRQoL) outcomes in OHCA survivors. Methods Between 2010 and 2016, consecutive adult OHCA survivors were invited to participate in structured telephone interviews using the Glasgow Outcome Scale-Extended (GOSE), the EuroQol-5D (EQ-5D), and 12-Item Short Form (SF-12) health survey. Results Of the 2300 patients discharged alive, 175 (7.6%) died during the follow-up period with the rate of death at 12 months being higher in women compared to men (10.4% vs. 6.4%; p = 0.002). Of the 2125 12 month survivors, 1752 (82.5%) participated in the interviews. Unadjusted outcomes were consistently poorer for females compared to males, with fewer women reporting good functional recovery (GOSE ≥ 7, 53.5% vs. 64.8%, p Conclusions Women report poorer functional recovery and HRQoL after OHCA. Further research is needed to better understand the reasons for these disparities.
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Deferred consent may be necessary because the therapeutic window is too narrow to obtain a valid preenrolment consent.
“Deferred consent (i.e. obtaining consent from a surrogate and/or patient as soon as possible after enrolment) may be necessary because the therapeutic window is too narrow to obtain a valid preenrolment consent. 63,317,322 324”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [322]
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Andrew, E., Mercier, E., Nehme, Z., Bernard, S., & Smith, K. (2018) · Resuscitation · doi:10.1016/j.resuscitation.2018.03.017 · Cited by 51 · see citing works
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European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions
Mentzelopoulos, S. D., Couper, K., Voorde, P. V. D., Druwé, P., Blom, M., Perkins, G. D., Lulic, I., Djakow, J., Raffay, V., Lilja, G., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.02.017 · Cited by 246 · see citing works
- Authors
- Nehme, Z., Andrew, E., Bernard, S., & Smith, K.
- Affiliations
- Ambulance Victoria (AU)
- The Alfred Hospital (AU)
- The University of Western Australia (AU)
- Corresponding author
- Nehme, Ziad
- Venue
- Resuscitation
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 137
- Pages
- 21-28
- ISSN
- 0300-9572 (ISSN-L)
- OpenAlex
- W2911743107
- Cited by
- 60
- References
- 1
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 5 · 2015: 1
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Resuscitation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (1146809)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- out-of-hospital cardiac arrest, sex differences, health-related quality of life, functional recovery, long-term outcomes, post-cardiac arrest syndrome, women, mortality, Glasgow Outcome Scale-Extended, EQ-5D, SF-12, mental health, physical health, return to work
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Sex Factors, Victoria, Cardiopulmonary Resuscitation, Survivors, Recovery of Function, Out-of-Hospital Cardiac Arrest
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