A novel asymmetric amphiphilic porous film of (PLA)-(PLA-b-PEG)-(PEG) with controlled gradual pore size
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A porous film of (PLA)-(PLA-b-PEG)-(PEG) is fabricated as a general biomedical device for potential applications. For the purpose of providing both mechanic strength and bio-friendly supporting, the film is designed to be asymmetric with a PLA-densed hydrophobic surface and a PEG-densed hydrophilic surface. Beyond the conventional technique to achieve amphiphilicity and porosity via simple blend of two typical biopolymers, a fine controlled processing is developed to achieve the gradual pore size along depth with the attendance of block polymer, which provides several advantages such as avoiding sharp phase separation, the gradual release of biofactors as a carrier, etc.
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Porogen leaching is the most common method to obtain a porous structure for this type of polymer blend.
“Porogen leaching is the most common method to obtain a porous structure for this type of polymer blend [178,179].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [179]
The Introduction says PEG can serve as a porogen to produce a porous PLA/PEG/PLA-b-PEG film through leaching, and the Methods describe leaching PEG from the film. The paper does not say porogen leaching is the most common method for this type of blend; that comparative claim is unsupported. (LLM, conf=0.88)
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Maharana, T., Mohanty, B., & Negi, Y. S. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.10.001 · Cited by 368 · see citing works
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
- Authors
- Huang, R., Zhou, B., Nie, Z., Ding, W., Jiang, X., & Song, Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Zhejiang University (CN)
- Corresponding author
- Huang, Ran
- Song, Yihu
- ORCID
- Huang, Ran
- Venue
- Results in Materials
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 6
- Pages
- 100089
- ISSN
- 2590-048X (ISSN-L)
- OpenAlex
- W3027094850
- Cited by
- 5
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Results in Materials (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Shanghai Science and Technology Enterprises Innovation Fund (1903H1G5100)
- Shanghai Pujiang Talent Grant (16PJ1431900)
- Taizhou Municipal Science and Technology Program (2015cls01, 2017cls02, 1701gy15, 1801gy16, 1902gy07)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- amphiphilic polymers, polylactic acid, polyethylene glycol, block copolymer self-assembly, hydrophilic and hydrophobic surfaces, controlled release, biodegradable polymer blends
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