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High levels of interleukin-6 in the exhaled breath condensate of patients with COPD
Open accessAbstract
BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation of the respiratory tract. METHODS We investigated the presence of interleukin-6 (IL-6: a cytokine secreted by monocytes/macrophages, T cells, B cells, fibroblasts, bone marrow stromal cells, keratinocytes and endothelial cells) in the exhaled breath condensate of 16 exsmokers with moderate COPD, 12 healthy non-smokers. IL-6 was measured by means of a specific enzyme immunoassay. RESULTS IL-6 levels were detectable in all of the subjects, but were higher in the COPD patients (8.0 +/- 0.1 pg/ml; P < 0.0001) than in the healthy non-smokers (4.9 +/- 0.2 pg/ml) with a correlation in this group between age and IL-6 levels (r = 0.597; P < 0.05). CONCLUSIONS The increased IL-6 levels in exhaled breath condensate may reflect airway inflammation in patients with COPD.
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Cited by
Exhaled breath condensate: methodological recommendations and unresolved questions
Horváth, I., Hunt, J., & Barnes, P. J. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00029705 · Cited by 1,284
Self-citationMediators of Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.2 · Cited by 710
Self-citationMacrophage heterogeneity in respiratory diseases
Boorsma, C. E., Draijer, C., & Melgert, B. N. (2013) · Mediators of Inflammation · doi:10.1155/2013/769214 · Cited by 126
Liu, X. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.147 · Cited by 33
Metadata
- Authors
- Bucchioni, E., Kharitonov, S. A., Allegra, L., & Barnes, P. J.
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 97
- Issue
- 12
- Pages
- 1299-1302
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W1969459009
- Cited by
- 168
- References
- 0
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bucchioni, E., Kharitonov, S. A., Allegra, L., & Barnes, P. J. (2003). High levels of interleukin-6 in the exhaled breath condensate of patients with COPD. Respiratory Medicine. https://doi.org/10.1016/j.rmed.2003.07.008
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