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Cited by 190Inhalation and Respiratory Drug DeliveryAsthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) Research

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Choosing inhaler devices for people with asthma: Current knowledge and outstanding research needs

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Haughney, John, Price, David, Barnes, Neil C., Virchow, J. Christian, Roche, Nicolas, Chrystyn, Henry·2010·Respiratory Medicine
DOI 10.1016/j.rmed.2010.04.012
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Abstract

Recommendations in asthma guidelines presuppose that practitioners have the evidence, information, knowledge, and tools to select inhaler devices appropriate for individual patients. Randomised controlled trials usually exclude patients with suboptimal inhaler technique. There is therefore little evidence on which to base inhaler selection in the real world, where patients often use their inhalers incorrectly. The lung deposition of inhaled drug varies according to inhaler device, drug particle size, inhalation technique, and pattern of inspiratory flow. Even with training, not all patients can use their inhalers correctly and maintain inhaler technique; patients may have inability to handle the inhaler, strong negative preferences, or natural breathing patterns that do not match their prescribed inhaler. Therefore, matching device to the patient may be a better course of action than increasing therapy or training and retraining a patient to use a specific inhaler device. Several research questions require answers to meet the goal of helping prescribers make a more informed choice of inhaler type. Is the level of drug deposition in the lungs a key determinant of clinical short- and long-term outcomes? What should be measured by a clinical tool designed to check inhaler technique and therefore help with device selection? If we have a tool to help in individualising inhaler choice, will we achieve better asthma outcomes? Do we have to refine inhaler device choice for each individual, or will we get better outcomes if we select our current best option in light of current knowledge and apply this on a population level?

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Metadata

Authors
Haughney, J., Price, D., Barnes, N. C., Virchow, J. C., Roche, N., & Chrystyn, H.
Affiliations
  • University of Aberdeen (GB)
  • London Chest Hospital (GB)
  • Universitätsmedizin Rostock (DE)
  • University of Huddersfield (GB)
Corresponding author
  • Haughney, John
  • Price, David
  • Barnes, Neil C.
  • Virchow, J. Christian
  • Chrystyn, Henry
ORCID
Venue
Respiratory Medicine
Publisher
Elsevier BV
Published
2010-09
Volume
104
Issue
9
Pages
1237-1245
ISSN
0954-6111 (ISSN-L)
DOI
10.1016/j.rmed.2010.04.012
OpenAlex
W2168551021
Cited by
190
References
0
Citations by year
2026: 6 · 2025: 4 · 2024: 13 · 2023: 9 · 2022: 8 · 2021: 9 · 2020: 15 · 2019: 19 · 2018: 17 · 2017: 20 · 2016: 14 · 2015: 14 · 2014: 13 · 2013: 11 · 2012: 7
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Respiratory Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • University of Huddersfield Repository (University of Huddersfield) (submittedVersion)
Funders
Mundipharma International
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
asthma, inhaler devices, inhaler selection, inhaler technique, lung deposition, pulmonary drug delivery, personalized treatment, patient preferences, drug particle size
MeSH terms
Asthma, Dose-Response Relationship, Drug, Humans, Nebulizers and Vaporizers, Particle Size, Patient Selection, Anti-Asthmatic Agents, Needs Assessment

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