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Cited by 110Biochemical Acid Research StudiesEnzyme Structure and FunctionAlcoholism and Thiamine Deficiency

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Structural biology of enzymes of the thiamin biosynthesis pathway

Settembre, Ethan, Begley, Tadhg P, Ealick, Steven E·2003·Current Opinion in Structural Biology
DOI 10.1016/j.sbi.2003.10.006
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Abstract

Thiamin pyrophosphate is an essential cofactor of carbohydrate and branched-chain amino acid metabolism. Although its mechanistic role is well studied, the biosynthesis of thiamin has only recently been understood. Thiamin biosynthesis in Escherichia coli and Bacillus subtilis show some similarities, but diverge at key steps of thiazole formation. The biosynthesis of thiamin in eukaryotes is at a very early stage of understanding. Structural and mechanistic studies on thiamin biosynthetic enzymes have played a key role in increasing our understanding of thiamin pyrophosphate biosynthesis and have revealed unexpected evolutionary ties.

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Metadata

Authors
Settembre, E., Begley, T. P., & Ealick, S. E.
Affiliations
Cornell University (US)
Corresponding author
Ealick, Steven E
ORCID
Venue
Current Opinion in Structural Biology
Publisher
Elsevier BV
Published
2003-12
Volume
13
Issue
6
Pages
739-747
ISSN
0959-440X (ISSN-L)
DOI
10.1016/j.sbi.2003.10.006
OpenAlex
W2080899182
Cited by
110
References
62
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 1
FWCI
0.54
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Current Opinion in Structural Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • W. M. Keck Foundation
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK44083)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
  • Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords
thiamine biosynthesis, thiamine pyrophosphate, thiazole biosynthesis, enzyme structure, enzyme mechanism, Escherichia coli, Bacillus subtilis, phylogenetic relationships, cofactor metabolism
MeSH terms
Bacteria, Multienzyme Complexes, Thiamine, Thiazoles, Signal Transduction

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Settembre, E., Begley, T. P., & Ealick, S. E. (2003). Structural biology of enzymes of the thiamin biosynthesis pathway. Current Opinion in Structural Biology. https://doi.org/10.1016/j.sbi.2003.10.006

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