Mass spectrometric analysis of N- and O-glycosylation of tissues and cells
Abstract
Mass spectrometry has been at the forefront of glycobiological analysis for more than two decades. Recent advances in technology, coupled with increased global appreciation of the importance of the glycome in solving biological problems, have laid the foundations for an unprecedented increase in output. Under the auspices of major international consortia, significant progress is being made towards the development of integrated databases of specific cell and tissue N- and O-glycan profiles. Tools for the automation of both sample handling and data analysis are enabling a more concerted approach to glycan structural analysis. When combined with complementary transcriptomics and bioinformatics analyses, these tools will facilitate a new systems glycobiology approach to research.
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MALDI and ESI are soft ionisation techniques that now dominate in the MS field.
“Matrix-assisted laser desorption/ionisation (MALDI) and electrospray ionisation (ESI) are ‘soft ionisation' techniques, which now dominate in the MS field [142,145].”
From Glycoengineering Chinese hamster ovary cells: a short history (2021) · cites this paper as [145]
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- Authors
- HASLAM, S., NORTH, S., & DELL, A.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- DELL, A
- Venue
- Current Opinion in Structural Biology
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 16
- Issue
- 5
- Pages
- 584-591
- ISSN
- 0959-440X (ISSN-L)
- OpenAlex
- W2090000207
- Cited by
- 111
- References
- 52
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 2
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Structural Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
- National Institute of General Medical Sciences (GM 62116, U54GM062116)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- N-glycosylation, O-glycosylation, glycan profiling, glycome, glycan structure analysis, glycan databases, transcriptomics integration, automated sample handling
- MeSH terms
- Animals, Carbohydrate Sequence, Glycosylation, Humans, Molecular Sequence Data, Polysaccharides, Mass Spectrometry
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