The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Gangliosides in cell recognition and membrane protein regulation
Open accessAbstract
Summary Gangliosides, sialic acid-bearing glycosphingolipids, are expressed on all vertebrate cells, and are the major glycans on nerve cells. They are anchored to the plasma membrane through their ceramide lipids with their varied glycans extending into the extracellular space. Through sugar-specific interactions with glycan binding proteins on apposing cells, gangliosides function as receptors in cell-cell recognition, regulating natural killer cell cytotoxicity via Siglec-7 binding, myelin-axon interactions via Siglec-4 (myelin-associated glycoprotein) binding, and inflammation via E-selectin binding. Gangliosides also interact laterally in their own membranes, regulating the responsiveness of signaling proteins including the insulin, epidermal growth factor and vascular endothelial growth factor receptors. In these ways, gangliosides act as regulatory elements in the immune system, in the nervous system, in metabolic regulation and in cancer progression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 6,929
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653
GLYCAM06: A generalizable biomolecular force field. Carbohydrates
Kirschner, K. N., Yongye, A. B., Tschampel, S. M., González‐Outeiriño, J., Daniels, C. R., Foley, B. L., & Woods, R. J. (2008) · Journal of Computational Chemistry · doi:10.1002/jcc.20820 · Cited by 2,243
Siglecs and their roles in the immune system
Crocker, P. R., Paulson, J. C., & Varki, A. (2007) · Nature Reviews Immunology · doi:10.1038/nri2056 · Cited by 2,031
Glial inhibition of CNS axon regeneration
Yiu, G., & He, Z. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1956 · Cited by 1,495
Peripheral neuropathies and anti-glycolipid antibodies
Willison, H. J. (2002) · Brain · doi:10.1093/brain/awf272 · Cited by 710
Bremer, E. G., Schlessinger, J., & Hakomori, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35954-9 · Cited by 706
Enhanced insulin sensitivity in mice lacking ganglioside GM3
Yamashita, T., Hashiramoto, A., Haluzik, M., Mizukami, H., Beck, S., Norton, A., Kono, M., Tsuji, S., Daniotti, J. L., Werth, N., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0635898100 · Cited by 531
PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration
Atwal, J. K., Pinkston-Gosse, J., Syken, J., Stawicki, S., Wu, Y., Shatz, C., & Tessier-Lavigne, M. (2008) · Science · doi:10.1126/science.1161151 · Cited by 502
Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects
Sheikh, K. A., Sun, J., Liu, Y., Kawai, H., Crawford, T. O., Proia, R. L., Griffin, J. W., & Schnaar, R. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7532 · Cited by 396
Self-citation
Cited by
Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
Merrill, A. H. (2011) · Chemical Reviews · doi:10.1021/cr2002917 · Cited by 785
Regulation of human EGF receptor by lipids
Coskun, Ü., Grzybek, M., Drechsel, D., & Simons, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105666108 · Cited by 316
Sweet complementarity: the functional pairing of glycans with lectins
Gabius, H.-J., Manning, J. C., Kopitz, J., André, S., & Kaltner, H. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2163-8 · Cited by 74
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution
Wang, X., Mitra, N., Secundino, I., Banda, K., Cruz, P., Padler-Karavani, V., Verhagen, A., Reid, C., Lari, M., Rizzi, E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119459109 · Cited by 72
Herzer, S., Hagan, C., von Gerichten, J., Dieterle, V., Munteanu, B., Sandhoff, R., Hopf, C., & Nordström, V. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00206 · Cited by 27
Metadata
- Authors
- Lopez, P. H., & Schnaar, R. L.
- Venue
- Current Opinion in Structural Biology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 19
- Issue
- 5
- Pages
- 549-557
- ISSN
- 0959-440X (ISSN-L)
- OpenAlex
- W2006073788
- Cited by
- 311
- References
- 54
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Gangliosides in cell recognition and membrane protein regulation. https://app.cochat.ai/papers/10.1016/j.sbi.2009.06.001
- The paper
- Lopez, P. H., & Schnaar, R. L. (2009). Gangliosides in cell recognition and membrane protein regulation. Current Opinion in Structural Biology. https://doi.org/10.1016/j.sbi.2009.06.001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
