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Cited by 178Schizophrenia research and treatmentPsychiatric care and mental health servicesMental Health Treatment and Access

Transition rates from schizotypal disorder to psychotic disorder for first-contact patients included in the OPUS trial. A randomized clinical trial of integrated treatment and standard treatment

Nordentoft, Merete, Thorup, Anne, Petersen, Lone, Øhlenschlæger, Johan, Melau, Marianne, Christensen, Torben Østergaard, Krarup, Gertrud, Jørgensen, Per +1 more·2006·Schizophrenia Research
DOI 10.1016/j.schres.2006.01.002
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Abstract

Background Only a few randomized clinical trials have tested the effect on transition rates of intervention programs for patients with sub-threshold psychosis-like symptoms.Aim To examine whether integrated treatment reduced transition to psychosis for first-contact patients diagnosed with schizotypal disorder.Methods Seventy-nine patients were randomized to integrated treatment or standard treatment. Survival analysis with multivariate Cox-regression was used to identify factors determinant for transition to psychotic disorder.Results In the multivariate model, male gender increased risk for transition to psychotic disorder (relative risk=4.47, (confidence interval 1.30-15.33)), while integrated treatment reduced the risk (relative risk=0.36 (confidence interval 0.16-0.85)). At two-year follow-up, the proportion diagnosed with a psychotic disorder was 25.0% for patients randomized to integrated treatment compared to 48.3% for patients randomized to standard treatment.Conclusion Integrated treatment postponed or inhibited onset of psychosis in significantly more cases than standard treatment.

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Crossref · 10.1016/j.schres.2006.01.002

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  • The Stafford et al meta-analysis analyzed 11 studies, but one was open-label and another did not use standard clinical high risk for psychosis criteria, leaving nine studies with 1,043 patients in common with the current study.

    “For example, the metaanalysis by Stafford et al 15 -on which current clinical guidelines are based -analyzed 11 studies, but one of them included an open-label trial (N5124) 94 and another did not assess participants against standard CHR-P criteria (N579) 20 , leaving nine studies (N51,043) that are in common with the current”

    From Lack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis (2018) · cites this paper as [20]

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References 31 · Cited by 178

Authors
Nordentoft, M., Thorup, A., Petersen, L., Øhlenschlæger, J., Melau, M., Christensen, T. Ø., Krarup, G., Jørgensen, P., & Jeppesen, P.
Affiliations
  • Bispebjerg Hospital (DK)
  • Sankt Hans Hospital (DK)
Corresponding author
Nordentoft, Merete
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2006-03
Volume
83
Issue
1
Pages
29-40
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2006.01.002
OpenAlex
W2021060992
Cited by
178
References
31
Citations by year
2026: 5 · 2025: 4 · 2024: 5 · 2023: 15 · 2022: 4 · 2021: 7 · 2020: 13 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 10
FWCI
4.04
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
World Health Organization
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
schizotypal personality disorder, transition to psychosis
MeSH terms
Adult, Combined Modality Therapy, Community Mental Health Services, Continuity of Patient Care, Denmark, Female, Humans, Male, Prospective Studies, Psychotherapy, Psychotic Disorders, Schizophrenia, Schizotypal Personality Disorder, Antipsychotic Agents, Multivariate Analysis, Proportional Hazards Models, Disease Progression, Delivery of Health Care, Integrated

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