Effects of four atypical antipsychotics on autonomic nervous system activity in schizophrenia
Abstract
Antipsychotic drugs are associated with autonomic nervous system (ANS) dysfunction in patients with schizophrenia, but the effects of individual atypical antipsychotic drugs are not clear. This study investigated how four atypical antipsychotic drugs-risperidone, olanzapine, aripiprazole, and quetiapine-differ in their effects on ANS activity. A total of 241 Japanese patients with schizophrenia participated in this study. All of the participants received an atypical antipsychotic as monotherapy: 90 participants received risperidone, 68 olanzapine, 52 aripiprazole, and 31 quetiapine. ANS activity was assessed by means of a power spectral analysis of heart rate variability. The quetiapine group showed significantly diminished sympathetic and parasympathetic activity compared with the risperidone and aripiprazole groups and significantly lower sympathetic activity relative to olanzapine. In addition, multiple regression analysis showed that the type of antipsychotic drug significantly influenced ANS activity. We suggest that, among the antipsychotics examined-risperidone, olanzapine, aripiprazole and quetiapine-quetiapine has the strongest effect on ANS activity.
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There is a negative correlation between neurocardiac control and the degree of antipsychotic affinity and antagonism of muscarinic receptors, with high muscarinic affinity antipsychotics clozapine, olanzapine and quetiapine showing greater reductions in heart rate variability than low muscarinic affinity antipsychotics risperidone and aripiprazole.
“There appears to be a negative correlation between neurocardiac control and the degree of AP affinity and antagonism of muscarinic receptors (M1-M5), with high muscarinic affinity APs (clozapine, olanzapine and quetiapine) showing greater reductions in HRV than low muscarinic affinity APs (risperidone and aripiprazole)48–50.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [49]
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References 37 · Cited by 29
- Authors
- Hattori, S., Kishida, I., Suda, A., Miyauchi, M., Shiraishi, Y., Fujibayashi, M., Tsujita, N., Ishii, C., Ishii, N., Moritani, T., Taguri, M., & Hirayasu, Y.
- Affiliations
- Yokohama City University (JP)
- Fujisawa City Hospital (JP)
- Setsunan University (JP)
- Kyoto University (JP)
- Kyoto Sangyo University (JP)
- Corresponding author
- Hattori, Saki
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 193
- Pages
- 134-138
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2735273094
- Cited by
- 29
- References
- 37
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 1
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (15K19740, 15K01610, 16K10254)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- atypical antipsychotics, autonomic dysfunction
- MeSH terms
- Aripiprazole, Quetiapine Fumarate, Olanzapine, Aged, Analysis of Variance, Autonomic Nervous System Diseases, Benzodiazepines, Cross-Sectional Studies, Electrocardiography, Female, Heart Rate, Humans, Japan, Male, Middle Aged, Psychiatric Status Rating Scales, Retrospective Studies, Schizophrenia, Antipsychotic Agents, Risperidone
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