Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation
Open accessAbstract
The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway that regulates cell proliferation and organ growth. Here we provide a brief overview of the Hippo/Yap pathway and its known roles in the developing and adult heart. We discuss the implications of Hippo/Yap signaling for regulation of cardiomyocyte death and regeneration.
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Yap loss- or gain-of-function in the embryonic heart is frequently lethal.
“Several studies show that Yap loss- or gainof-function in the embryonic heart is frequently lethal (reviewed by (84, 141, 155)).”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [84]
The cardiac hypertrophy and apoptosis section reports that two studies found premature death after late-fetal cardiac Yap inactivation. The heart-development section reports hypoplasia with early YAP loss and overgrowth with YAP gain, but does not say that gain of function was lethal or establish that either manipulation was frequently lethal. The heart-regeneration section notes that some mice with embryonic YAP overexpression survived to adulthood. (LLM, conf=0.86)
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References 77 · Cited by 52
- Authors
- Lin, Z., & Pu, W. T.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Pu, William T.
- Venue
- Stem Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 13
- Issue
- 3
- Pages
- 571-581
- ISSN
- 1873-5061 (ISSN-L)
- PMC
- PMC4223001
- OpenAlex
- W1967359849
- Cited by
- 52
- References
- 77
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 9 · 2016: 8 · 2015: 4
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIH (HL116461, HL100401)
- American Heart Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- Hippo signaling pathway, YAP, cardiac regeneration, cardiomyocyte death, myocardial injury, heart failure, cardiomyocyte proliferation, heart development, organ growth regulation
- MeSH terms
- Hippo Signaling Pathway, YAP-Signaling Proteins, Animals, Heart, Heart Diseases, Humans, Phosphoproteins, Regeneration, Rejuvenation, Transcription Factors, Signal Transduction, Protein Serine-Threonine Kinases, Myocytes, Cardiac, Adaptor Proteins, Signal Transducing
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