Generation of induced pluripotent stem cells derived from a 77-year-old healthy woman as control for age related diseases
Open accessAbstract
Induced pluripotent stem cells (iPSCs) hold great promise to model diseases, where the disease affected cell type is difficult to access. A major obstacle for the development of disease models is the lack of well characterized control iPSCs from old people not affected by such a disease. Furthermore, gene-editing approaches often require iPSCs from healthy donors, where pathogenic mutations can be inserted if patient material is not available. Here, we report the generation of an iPSC line (16423 #6) from a 77-year-old woman, who did not display any disease symptoms at the time, when the skin biopsy was taken.
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The study used two isogenic iPSC sets (KOLF2.1J and BIONi037) to ensure rigor and reproducibility.
“To ensure rigor and reproducibility, we chose to isolate lipid droplets from human iPSC-derived astrocytes derived from two iPSC sets (KOLF2.1 J and BIONi037)38,39(Fig. 1A).”
From APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics (2026) · cites this paper as [38]
The Resource details section (pp. 550–552) names the generated line hiPSC-16423 #6 and mentions BIONi010-C as a comparison line. Searches for BIONi037, KOLF2.1J, isogenic sets, astrocytes, and lipid droplets found no passage establishing that this paper identifies either set cited in the sentence; the different line names alone do not rule out an alias. (LLM, conf=0.75)
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Cuní-López, C., Root, J. T., Hao, Y., Blomberg, N., Koppes-den Hertog, S. J., Sacks, D., Trujillo, A. E., Ghirlando, R., Kowal, I., Epstein, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76565-6
- Authors
- Nimsanor, N., Jørring, I., Rasmussen, M. A., Clausen, C., Mau-Holzmann, U. A., Bus, C., Hoffmann, S. A., Gasser, T., Kluba, T., Holst, B., & Schmid, B.
- Affiliations
- Mahidol University (TH)
- Bioneer (Denmark) (DK)
- University of Tübingen (DE)
- German Center for Neurodegenerative Diseases (DE)
- Corresponding author
- Schmid, Benjamin
- Venue
- Stem Cell Research
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 17
- Issue
- 3
- Pages
- 550-552
- ISSN
- 1873-5061 (ISSN-L)
- OpenAlex
- W2527283678
- Cited by
- 7
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2018: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion, cc-by-nc-nd)
- Funders
- The Danish Agency for Science, Technology and Innovation (6114-00003B-768138, PIAPP-GA-2012-324451)
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework
- BrainStem – Stem cell Centre of Excellence in Neurology (4108-00008B)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- induced pluripotent stem cells, genome editing
- MeSH terms
- Aged, Cell Differentiation, Cell Line, Ectoderm, Female, Fibroblasts, Humans, Microscopy, Fluorescence, Skin, Transcription Factors, Induced Pluripotent Stem Cells, Karyotype, Healthy Volunteers, Cellular Reprogramming
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