Corrigendum to "Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line" [Stem Cell Res. 34/1873-5061 (2019) 101349-55]
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Isogenic APOE iPSCs obtained from EBiSC show mono-allelic expression of APOE, or APOE deletion.
“Isogenic APOE iPSCs were obtained from the European Bank for Induced Pluripotent Stem Cells (EBiSC), and show mono-allelic expression of APOE, or APOE deletion (Schmid et al., 2019, 2020).”
From APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes (2022) · cites this paper as Schmid et al., 2020
The iPSC lines used harbor a single APOE2, APOE3, or APOE4 allele generated using CRISPR, or an APOE-KO generated by an insertion-deletion mutation in exon 2.
“iPSC lines were purchased from EBiSC (BIONi010-C-2, -C-3, C-4, and -C-6), harboring a single APOE2, APOE3, or APOE4 allele generated using CRISPR, or an APOE-KO generated by an insertion-deletion mutation in exon 2 (Schmid et al., 2019, 2020).”
From APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes (2022) · cites this paper as Schmid et al., 2020
Cited by
Sorted by citations
de Leeuw, S. M., Kirschner, A. W. T., Lindner, K., Rust, R., Budny, V., Wolski, W. E., Gavin, A.-C., Nitsch, R. M., & Tackenberg, C. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.11.007 · Cited by 105 · see citing works
APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons
Budny, V., Knöpfli, Y., Meier, D., Zürcher, K., Bodenmann, C., Peter, S. L., Müller, T., Tardy, M., Cortijo, C., & Tackenberg, C. (2024) · Cells · doi:10.3390/cells13141207 · Cited by 15 · see citing works
APOE genotype-dependent differences in human astrocytic energy metabolism
Budny, V., Bodenmann, C., Zürcher, K. J., Krüger, M., de Leeuw, S. M., Weber, R. Z., Rust, R., Ravotto, L., Ruminot, I., Barros, L. F., et al. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1603657 · Cited by 6 · see citing works
- Authors
- Schmid, B., Prehn, K. R., Nimsanor, N., Garcia, B. I. A., Poulsen, U., Jørring, I., Rasmussen, M. A., Clausen, C., Mau-Holzmann, U. A., Ramakrishna, S., Muddashetty, R., Steeg, R., Bruce, K., Mackintosh, P., Ebneth, A., Holst, B., & Cabrera-Socorro, A.
- Affiliations
- Bioneer (Denmark) (DK)
- Mahidol University (TH)
- University of Tübingen (DE)
- University of Trans-Disciplinary Health Sciences and Technology (IN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Janssen (Belgium) (BE)
- ORCID
- Venue
- Stem Cell Research
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 48
- Pages
- 102005
- ISSN
- 1873-5061 (ISSN-L)
- OpenAlex
- W3088861089
- Cited by
- 12
- References
- 0
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Horizon 2020 Framework Programme
- Innovative Medicines Initiative (115975)
- European Federation of Pharmaceutical Industries and Associations
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- apolipoprotein E, isogenic cell lines, induced pluripotent stem cells, genome editing, apolipoprotein E deficiency, Alzheimer's disease
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