Histone acetylation in drug addiction
Open accessAbstract
Regulation of chromatin structure through post-translational modifications of histones (e.g., acetylation) has emerged as an important mechanism to translate a variety of environmental stimuli, including drugs of abuse, into specific changes in gene expression. Since alterations in gene expression are thought to contribute to the development and maintenance of the addicted state, recent efforts are aimed at identifying how drugs of abuse alter chromatin structure and the enzymes which regulate it. This review discusses how drugs of abuse alter histone acetylation in brain reward regions, through which enzymes this occurs, and ultimately what role histone acetylation plays in addiction-related behaviors.
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References 85 · Cited by 109
Research works printed but not linked: 1
- [84]Tsankova N Berton O Renthal W Kumar A Neve R Nestler E Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action Nat Neurosci 2006 9 519 25 16501568
- Authors
- Renthal, W., & Nestler, E. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Nestler, Eric J.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 20
- Issue
- 4
- Pages
- 387-394
- ISSN
- 1084-9521 (ISSN-L)
- PMC
- PMC2704458
- OpenAlex
- W2037189426
- Cited by
- 109
- References
- 85
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 10 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 14
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Texas Southwestern Medical Center
- National Institute on Drug Abuse (P01DA008227, R01DA007359, R01DA014133)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- histone acetylation, drug addiction, chromatin structure, post-translational modification, histone acetyltransferase, histone deacetylase, gene expression regulation
- MeSH terms
- Acetylation, Animals, Histones, Humans, Protein Processing, Post-Translational, Substance-Related Disorders
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