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Cited by 151Genetic and rare skin diseases.Hair Growth and DisordersDermatology and Skin Diseases

Development and homeostasis of the sebaceous gland

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Niemann, Catherin, Horsley, Valerie·2012·Seminars in Cell & Developmental Biology
DOI 10.1016/j.semcdb.2012.08.010PMC PMC5595243
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Abstract

The important role of epidermal appendages especially the sebaceous gland has only recently been recognized. In particular, it has been convincingly shown that normal development and maintenance of the sebaceous gland are required for skin homeostasis since atrophic sebaceous glands and disturbances in sebaceous lipid composition result in major defects of the physiological barrier and maintenance of the skin. Consequently, it is important to unravel the signaling network controlling proper sebaceous lineage differentiation in mammalian skin and to understand the underlying mechanisms leading to severe skin diseases, including abnormal proliferation and differentiation of the gland, defects of the lipid metabolism and barrier, as well as sebaceous tumor formation. Over the last years, results from transgenic and knock out mouse models manipulating distinct signaling pathways in the skin as well as the detailed analysis of human sebaceous gland-derived cell lines provided new insights into crucial mediators balancing proliferation and differentiation of the sebaceous gland. Here, we discuss our current knowledge of in vivo mechanisms of sebaceous gland development, maintenance and disorders and highlight recent contributions to the field of sebaceous gland biology.

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  • During SG homeostasis, SGPZ cells migrate inward, become post-mitotic, and differentiate to lipid-filled sebocytes.

    “During SG homeostasis, SGPZ cells migrate inward, become post-mitotic and differentiate to lipid-filled sebocytes (Fig. 2a)1, 22.”

    From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [1]

    Section 2 (page unavailable) describes proliferative cells at the gland’s periphery replenishing sebocytes, which accumulate lipids and are pushed toward the center. Section 3 calls mature sebocytes postmitotic, but does so for the developing gland. The copy therefore supports the broad maturation sequence, not the specific account that SGPZ cells themselves migrate inward and become postmitotic during homeostasis. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • In the SG, cell proliferation is restricted to basal cells in the SG proliferative zone (SGPZ).

    “In the SG, cell proliferation is restricted to basal cells, which reside at a defined region known as the SG proliferative zone (SGPZ).”

    From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [1]

    Section 2, “Organization and Functions of the Sebaceous Gland” (page unavailable), describes a proliferative basal layer at the gland’s periphery and says basal-cell division sustains renewal. It does not call this region the “SG proliferative zone” (SGPZ) or explicitly state that proliferation is restricted to it. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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References 100 · Cited by 151

Research works printed but not linked: 91

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Authors
Niemann, C., & Horsley, V.
Affiliations
  • University of Cologne (DE)
  • Yale University (US)
Corresponding author
Niemann, Catherin
ORCID
Venue
Seminars in Cell & Developmental Biology
Publisher
Elsevier BV
Published
2012-10
Volume
23
Issue
8
Pages
928-936
ISSN
1084-9521 (ISSN-L)
DOI
10.1016/j.semcdb.2012.08.010
PMC
PMC5595243
OpenAlex
W1986742514
Cited by
151
References
100
Citations by year
2026: 15 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 19 · 2021: 10 · 2020: 7 · 2019: 16 · 2018: 11 · 2017: 5 · 2016: 9 · 2015: 11 · 2014: 10 · 2013: 4
FWCI
0.98
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Seminars in Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR060295, R00AR054775, K99AR054775)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
sebaceous glands, skin homeostasis, epidermal appendages, sebaceous gland atrophy, sebaceous lipids, skin barrier, sebaceous tumors, signaling pathways, mouse model
MeSH terms
Animals, Homeostasis, Humans, Sebaceous Glands, Skin Diseases, Transcription, Genetic, Signal Transduction

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