Regeneration: The ultimate example of wound healing
Abstract
The outcome of wound repair in mammals is often characterized by fibrotic scaring. Vertebrates such as zebrafish, frogs, and salamanders not only heal scarlessly, but also can regenerate lost appendages. Decades of study on the process of animal regeneration has produced key insights into the mechanisms of how complex tissue is restored. By examining our current knowledge of regeneration, we can draw parallels with mammalian wound healing to identify the molecular determinants that produce such differing outcomes.
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Zebrafish can regenerate missing fins, and salamanders can regenerate whole limbs.
“Zebrafish can grow back missing fins, whereas salamanders are famously able to regenerate whole limbs (130).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [130]
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References 84 · Cited by 71
- Authors
- Murawala, P., Tanaka, E. M., & Currie, J. D.
- Affiliations
- Center for Regenerative Therapies Dresden (DE)
- Corresponding author
- Tanaka, Elly M.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 23
- Issue
- 9
- Pages
- 954-962
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W1963498034
- Cited by
- 71
- References
- 84
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 8
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- regeneration, wound healing, scarless wound healing, fibrosis, appendage regeneration, zebrafish, amphibian regeneration
- MeSH terms
- Epidermal Cells, Animals, Anura, Cell Movement, Cicatrix, Epidermis, Extracellular Matrix, Fibroblasts, Mammals, Regeneration, Species Specificity, Caudata, Wound Healing, Keratinocytes, Dermis, Re-Epithelialization
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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