Neurodevelopmental outcome in children with congenital heart disease
Abstract
Children with congenital heart disease (CHD) have multiple factors contributing toward their risk of later neurodevelopmental difficulties. With earlier diagnosis and improved survival rates, the management of CHD now includes the recognition of neurodevelopmental risks and optimisation of neurodevelopmental outcomes is emphasised. Neuroimaging studies have shown early differences in brain development for children with CHD, who then are vulnerable to additional brain injury in the perinatal period. For some children, complications and co-morbidities may further increase the risk of brain injury. Synthesis of multiple factors is necessary to estimate neurodevelopmental prognosis for an individual child. Long-term neurodevelopmental follow-up of children with CHD is warranted for early identification of and intervention for difficulties.
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People who survive congenital heart disease continue to show functional deficits during early childhood and adolescence.
“However, survivors of CHD continue to show functional deficits in early childhood and adolescence.[2][3][4][5]”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [2]
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References 57 · Cited by 53
- Authors
- Martinez-Biarge, M., Jowett, V. C., Cowan, F. M., & Wusthoff, C. J.
- Affiliations
- Queen Charlotte's and Chelsea Hospital (GB)
- Hammersmith Hospital (GB)
- Stanford Medicine (US)
- Corresponding author
- Wusthoff, Courtney J.
- Venue
- Seminars in Fetal and Neonatal Medicine
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 18
- Issue
- 5
- Pages
- 279-285
- ISSN
- 1744-165X (ISSN-L)
- OpenAlex
- W1979430152
- Cited by
- 53
- References
- 57
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 9 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 6
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Fetal and Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- congenital heart disease, neurodevelopmental outcomes, neurodevelopmental risk factors, brain injury, perinatal brain injury, neuroimaging, neurodevelopmental prognosis, long-term follow-up
- MeSH terms
- Child Development, Female, Heart Defects, Congenital, Heart Diseases, Humans, Infant, Newborn, Male, Nervous System Malformations, Nervous System Diseases, Pregnancy, Fetal Development, Neurogenesis
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