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Cited by 758Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceUrinary Tract Infections Management

Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment

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Shaikh, Sibhghatulla, Fatima, Jamale, Shakil, Shazi, Rizvi, Syed Mohd. Danish, Kamal, Mohammad Amjad·2015·Saudi Journal of Biological Sciences
DOI 10.1016/j.sjbs.2014.08.002PMC PMC4281622
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Abstract

Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Rapid detection in clinical laboratories is essential for the judicious recognition of antimicrobial resistant organisms. Production of extended-spectrum β-lactamases (ESBLs) is a significant resistance-mechanism that impedes the antimicrobial treatment of infections caused by Enterobacteriaceae and is a serious threat to the currently available antibiotic armory. ESBLs are classified into several groups according to their amino acid sequence homology. Proper infection control practices and barriers are essential to prevent spread and outbreaks of ESBL producing bacteria. As bacteria have developed different strategies to counter the effects of antibiotics, the identification of the resistance mechanism may help in the discovery and design of new antimicrobial agents. The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce. Hence, more expeditious diagnostic testing of ESBL-producing bacteria and the feasible modification of guidelines for community-onset bacteremia associated with different infections are prescribed.

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  • E. coli and K. pneumoniae can cause severe infections and have multiple resistance mechanisms, such as extended-spectrum beta-lactamase (ESBL) and carbapenemase production.

    “MDR was commonly observed among members of the Enterobacteriaceae, including E. coli and K. pneumoniae, which can cause severe infections and have multiple resistance mechanisms, such as extended-spectrum beta-lactamase (ESBL) and carbapenemase production [28,66,67].”

    From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [66]

    The Introduction identifies E. coli and K. pneumoniae as multidrug-resistant pathogens, and Treatment describes serious infections caused by ESBL-producing strains of both. Epidemiology discusses the NDM-1 carbapenemase in Enterobacteriaceae, but does not specifically establish carbapenemase production in both named species. (LLM, conf=0.83)

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Cited by

Sorted by citations

Authors
Shaikh, S., Fatima, J., Shakil, S., Rizvi, S. M. D., & Kamal, M. A.
Affiliations
  • Integral University (IN)
  • King Abdulaziz University (SA)
Corresponding author
Shakil, Shazi
ORCID
Venue
Saudi Journal of Biological Sciences
Publisher
Elsevier BV
Published
2015-01
Volume
22
Issue
1
Pages
90-101
ISSN
1319-562X (ISSN-L)
DOI
10.1016/j.sjbs.2014.08.002
PMC
PMC4281622
OpenAlex
W2068319625
Cited by
758
References
0
Citations by year
2026: 28 · 2025: 58 · 2024: 83 · 2023: 71 · 2022: 91 · 2021: 79 · 2020: 90 · 2019: 94 · 2018: 79 · 2017: 53 · 2016: 25 · 2015: 5 · 2014: 1
FWCI
12.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Saudi Journal of Biological Sciences (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
DST (IF130056)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
Keywords
antibiotic resistance, extended-spectrum beta-lactamase, ESBL-producing Enterobacteriaceae, carbapenems, infection control, antibiotic resistance mechanisms, community-onset bacteremia, ESBL detection, antimicrobial therapy

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