The DOI matches its Crossref record; 41 of the 44 references it cites were found in a registry or an index.
Melatonin receptors: Role on sleep and circadian rhythm regulation
Abstract
The circadian release of the hormone melatonin is regulated by the suprachiasmatic nucleus (SCN), which feeds back into the nucleus to modulate sleep and circadian phase through activation of the MT(1) and/or MT(2) melatonin receptors. Considering the functions of the SCN as a sleep and circadian rhythm regulator, melatonin and melatonin receptor agonists have attracted interest as being possible treatments for sleep and circadian rhythm sleep disorders. Part of this interest has centered on elucidating which melatonin receptors are targets for the regulation of these functions within the SCN. Two G-protein coupled melatonin receptors, the MT(1) and MT(2), inhibit neuronal activity and phase shift circadian firing rhythms in the SCN, respectively. Recent reports have uncovered possible interactions between the two types of receptors in the mammalian SCN, as well as the role of physiological and supraphysiological levels of melatonin on the molecular pharmacology and cellular changes of human and rodent melatonin receptors via desensitization and internalization mechanisms. These data outline the complexity of the interplay between melatonin and its receptors in the SCN and their corresponding roles in sleep and circadian regulation. Although further studies are necessary, a great deal of progress has been made toward understanding how melatonin and its agonists contribute to sleep and circadian phase changes, and how best to develop compounds that can target the functions of the SCN specifically and effectively.
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“Melatonin not only mediates seasonal changes, but also affects influences circadian rhythms and sleep [see (Dubocovich, 2007), for review].”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Dubocovich, 2007
Citations
Cites
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Reiter, R. J. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923947 · Cited by 997
Functional MT1 and MT2 Melatonin Receptors in Mammals
Dubocovich, M. L., & Markowska, M. (2005) · Endocrine · doi:10.1385/endo:27:2:101 · Cited by 832
Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock
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Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist
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3 of the 44 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Hudson, 2005, Distinct roles for MT1 and MT2 melatonin (MLT) receptors in MLT-mediated phase shifts of circadian rhythms, Neuropsychopharmacology, 30, S267
- Hudson, 2004, Melatonin (MLT) phase advances the circadian rhythm of neuronal firing rate in suprachiasmatic nucleus (SCN) slices of C57BL/6 mice through activation of MT2 MLT receptors, FASEB J, 18
Cited by
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Items 101–103 of 103
Bai, C., Li, X., Gao, Y., Yuan, Z., Hu, P., Wang, H., Liu, C., Guan, W., & Ma, Y. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12334 · Cited by 43
Delayed sleep-wake phase disorder and its related sleep behaviors in the young generation.
Futenma, K., Takaesu, Y., Komada, Y., Shimura, A., Okajima, I., Matsui, K., Tanioka, K., & Inoue, Y. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1174719 · Cited by 42
Furster, C., & Hallerbäck, M. U. (2015) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-015-1866-3 · Cited by 19
Metadata
- Authors
- Dubocovich, M. L.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Dubocovich, Margarita L.
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 8
- Pages
- 34-42
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W2046526031
- Cited by
- 364
- References
- 44
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 20 · 2023: 21 · 2022: 39 · 2021: 36 · 2020: 32 · 2019: 13 · 2018: 23 · 2017: 19 · 2016: 13 · 2015: 15 · 2014: 16 · 2013: 18 · 2012: 17
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (MH 42922, MH52685)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- melatonin receptors, MT1 receptor, MT2 receptor, suprachiasmatic nucleus, circadian rhythm, sleep regulation, circadian phase shift, G protein-coupled receptors, receptor desensitization, receptor internalization, melatonin receptor agonists, sleep disorders, circadian rhythm sleep disorders
- MeSH terms
- Circadian Rhythm, Humans, Melatonin, Receptors, Cell Surface, Sleep, Suprachiasmatic Nucleus, Receptor, Melatonin, MT1, Receptor, Melatonin, MT2
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