Characterisation of sleep disturbances in postural orthostatic tachycardia syndrome: a polysomnography-based study
Abstract
Background and aim Postural orthostatic tachycardia syndrome (PoTS) has been frequently associated with sleep disturbances but objective sleep data are lacking. In addition, although regional autonomic denervation has been described, less is known about autonomic nervous activity overnight in these patients. Patients/methods A full polysomnography and heart rate variability were performed on 37 patients diagnosed with PoTS . In addition, a multiple sleep latency test (MSLT) was conducted on a subgroup of patients with excessive daytime sleepiness. Results The polysomnographic data did not show major pathological findings except the percentage spent in rapid eye movement (REM) sleep which was slightly reduced at 18.4%. The MSLT did not confirm excessive daytime sleepiness as median mean sleep latency was 14.4 min (11.8-17.5). When comparing patients with and without subjective daytime sleepiness, it was found that the latter had a reduced parasympathetic activation at night as expressed by the average high frequency [6936.5 ms(2) (6028.2-8675.5) vs. 4689.5 (3922.7-7685.2) p Conclusion Patients with PoTS do not exhibit polysomnographic findings consistent with relevant sleep pathologies nor objective daytime sleepiness. Subjective daytime sleepiness is associated with enhanced activation of the parasympathetic nervous system.
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In POTS patients who do get overnight polysomnography, no objective sleep parameter abnormalities are typically identified, and findings are comparable to those of healthy controls.
“In POTS patients who do get overnight polysomnography, no objective sleep parameter abnormalities are typically identified, and findings are comparable to those of healthy controls (84,85).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [85]
Cites
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“Postural orthostatic tachycardia syndrome (PoTS) is characterized by clinical features of orthostatic intolerance and an excessive increase in heart rate (by ≥30 or to ≥120 bpm) when upright [1].”
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Postural Orthostatic Tachycardia Syndrome
Bryarly, M., Phillips, L. T., Fu, Q., Vernino, S., & Levine, B. D. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.059 · Cited by 245 · see citing works
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Pharmacotherapy for postural tachycardia syndrome
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Multiple dimensions of excessive daytime sleepiness
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Self-citationKnoop, I., Picariello, F., Jenkinson, E., Gall, N., Chisari, C., & Moss-Morris, R. (2023) · Autonomic Neuroscience · doi:10.1016/j.autneu.2022.103052 · Cited by 21 · see citing works
“, 2014), over half experience sleep disturbances (Xu et al., 2016; Pederson and Blettner, 2017; Pengo et al., 2015; Bagai et al., 2014; Bagai et al., 2011; Raj et al., 2011) and many have mild to moderate anxiety symptoms (Raj et al.”
Self-citation
- Authors
- Pengo, M. F., Higgins, S., Drakatos, P., Martin, K., Gall, N., Rossi, G. P., & Leschziner, G.
- Affiliations
- Guy's Hospital (GB)
- King's College Hospital (GB)
- University of Padua (IT)
- Corresponding author
- Pengo, M.F.
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 16
- Issue
- 12
- Pages
- 1457-1461
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W1907273245
- Cited by
- 21
- References
- 3
- Citations by year
- 2022: 2 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 5
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- postural orthostatic tachycardia syndrome, sleep disorders, excessive daytime sleepiness, REM sleep, autonomic nervous system, parasympathetic activation, heart rate variability, multiple sleep latency test, autonomic denervation
- MeSH terms
- Adult, Female, Heart Rate, Humans, Male, Parasympathetic Nervous System, Sleep Wake Disorders, Sleep Stages, Polysomnography, Postural Orthostatic Tachycardia Syndrome
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